PROTAC tubulin-Degrader-1

PROTAC tubulin-Degrader-1 (Compound W13) (4-21 nM, 72 h) exhibits potent antiproliferative activity against multiple human tumor cell lines (MCF-7, A549, HepG2, MGC-803, HeLa, U937), with IC₅₀ values ranging from 0.004 μM to 0.021 μM^[1].
PROTAC tubulin-Degrader-1 (0-1.25 μM, 48 h) effectively degrades α-tubulin (DC₅₀ = 296 nM in A549, DC₅₀ = 32 nM in A549/Taxol), β-tubulin (DC₅₀ = 856 nM in A549, DC₅₀ = 972 nM in A549/Taxol) and potently degrades β3-tubulin (DC₅₀ = 251 nM in A549, DC₅₀ = 5 nM in A549/Taxol) in A549 and A549/Taxol cells^[1].
PROTAC tubulin-Degrader-1 (0.25 μM, 24-48 h) induces tubulin degradation via the ubiquitin-proteasome system (UPS)^[1].
PROTAC tubulin-Degrader-1 (2-50 nM, 24-48 h) induces G2/M phase arrest and promotes apoptosis in A549 and A549/Taxol cells in a dose-dependent manner^[1].
PROTAC tubulin-Degrader-1 (2-50 nM, 14 days) inhibits colony formation of A549 and A549/Taxol cells in a dose-dependent manner^[1].
PROTAC tubulin-Degrader-1 (2.5-10 nM, 6-8 h) strongly inhibits tube formation of human umbilical vein endothelial cells (HUVECs) on Matrigel, reducing the number of nodes, master junctions, segments length, total branching length and meshes in a dose-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.