country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-181143

Copy Link Print Information

PROTAC Tubulin degrader-2

PROTAC Tubulin degrader-2 is a cereblon (CRBN)-dependent α/β-tubulin PROTAC degrader with DC₅₀ values of 1.73 μM and 1.38 μM. PROTAC Tubulin degrader-2 can inhibit cancer cells proliferation and migration. PROTAC Tubulin degrader-2 can induce G2/M arrest, apoptosis, ROS accumulation. PROTAC Tubulin degrader-2 can be used for the research of cancer, such as non-small-cell lung cancer.
(Pink: α-Tubulin and β-Tubulin ligand (HY-N2146); Blue: Cereblon ligand (HY-A0003); Black: linker).

For research use only. We do not sell to patients.

Formula: C₄₀H₄₅N₅O₁₀
Molecular Weight:755.81

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PROTAC Tubulin degrader-2 Chemical Structure

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC Tubulin degrader-2 is a cereblon (CRBN)-dependent α/β-tubulin PROTAC degrader with DC₅₀ values of 1.73 μM and 1.38 μM. PROTAC Tubulin degrader-2 can inhibit cancer cells proliferation and migration. PROTAC Tubulin degrader-2 can induce G2/M arrest, apoptosis, ROS accumulation. PROTAC Tubulin degrader-2 can be used for the research of cancer, such as non-small-cell lung cancer^[1]. (Pink: α-Tubulin and β-Tubulin ligand (HY-N2146); Blue: Cereblon ligand (HY-A0003); Black: linker).

IC₅₀ & Target^[1]

Cereblon

α-tubulin

1.73 μM (DC₅₀)

β-tubulin

1.38 μM (DC₅₀)

All PROTACs Isoforms :

In Vitro

PROTAC Tubulin degrader-2 (Compound C02) (0.1-50 μM; 12-48 h) degrades α/β-tubulin in A549 cells with DC₅₀ values of 1.73 μM and 1.38 μM respectively, inhibits proliferation with an IC₅₀ of 0.71 μM^[1].
PROTAC Tubulin degrader-2 (0.5-2 μM; 12-48 h) induces G2/M arrest, apoptosis, ROS accumulation, and migration inhibition in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:

A549 cells
Concentration:

0.5, 1 and 2 μM
Incubation Time:

12, 24 and 36 h
Result:

Increased the proportion of A549 cells in the G2/M phase, reaching 43.1% at 24 h, compared to 9.6% in the untreated control.
Declined the proportion of G2/M cells after 36 h.

Apoptosis Analysis^[1]

Cell Line:

A549 cells
Concentration:

0.5, 1 and 2 μM
Incubation Time:

24 and 48 h
Result:

Increased the total numbers of late apoptosis cells from 3.9-13.1%.

Chemical Information

Molecular Weight 755.81
Formula C₄₀H₄₅N₅O₁₀
SMILES

O=C(NC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O)CCN4CCN(C(COC5=CC(/C=C\C6=CC(OC)=C(OC)C(OC)=C6)=CC=C5OC)=O)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang Y, et al. Design and synthesis of Cereblon-based PROTAC as novel potent degraders of α/β-tubulin[J]. Medicinal Chemistry Research, 2025: 1-14.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

PROTAC Tubulin degrader-2

All PROTACs Isoforms