1. Cell Cycle/DNA Damage
    Cytoskeleton
    Apoptosis
  2. Microtubule/Tubulin
    Apoptosis
  3. Eribulin mesylate

Eribulin mesylate (Synonyms: B1939 mesylate; E7389 mesylate; ER-086526 mesylate)

Cat. No.: HY-13442A Purity: 99.52%
Handling Instructions

Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used for the research of metastatic breast cancer. Eribulin mesylate inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

For research use only. We do not sell to patients.

Eribulin mesylate Chemical Structure

Eribulin mesylate Chemical Structure

CAS No. : 441045-17-6

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500 μg USD 1020 In-stock
Estimated Time of Arrival: December 31
1 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Eribulin mesylate (E7389 mesylate) is a microtubule targeting agent that is used for the research of metastatic breast cancer. Eribulin mesylate inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

In Vitro

Eribulin (1-100 nM; 72 h) inhibits cells proliferation, with IC50s of 22.8 and 21.5 nM for LM8 and Dunn cells, respectively[1].
Eribulin (10-50 nM; 12-72 h) increases early apoptosis significantly after 24 h treatment at the dose of 50 nM in LM8 cells[1].
Eribulin (10-50 nM; 12-72 h) induces G2/M arrest by 12 h treatment with at the dose of 50 nM, but not by long-term treatment (72 h) with 10 nM in LM8 cells[1].
Eribulin (1-50 nM; 12 h) does not induce senescence in LM8 cells[1].
Eribulin (1-10 nM; 16 h) induces morphological change and suppresses cell migration in a low concentration in LM8 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: LM8 cells and Dunn cells
Concentration: 0, 1, 10, 100 nM
Incubation Time: 72 hours
Result: Inhibited cells proliferation in a dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: LM8 cells
Concentration: 0, 10, 50 nM
Incubation Time: 12, 24, 48, 72 hour
Result: Induced early apoptosis after 12 h at the concentration of 50 nM.
Not detected apoptosis at the concentration of 10 nM.

Cell Cycle Analysis[1]

Cell Line: LM8 cells
Concentration: 0, 10, 50 nM
Incubation Time: 12, 24, 48, 72 hour
Result: Induced G2/M arrest by 12 h treatment with 50 nM.
No G2/M arrest was induced by10 nM treatment.
In Vivo

Eribulin (1 mg/kg; i.v. once a week for 2 weeks) reduces primary tumor growth and lung metastasis of osteosarcoma in mice[1].
Eribulin (1 mg/kg; once i.v.) suppresses circulating tumor cells (CTC) appearance in the low-concentration phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H/HeN mice (4-week-old) are injected LM8 cells[1]
Dosage: 1 mg/kg
Administration: I.v. once a week for 2 weeks
Result: Suppressed primary tumor growth and induced apoptosis in tumor cells. Reduced lung metastasis.
Clinical Trial
Molecular Weight

826.00

Formula

C₄₁H₆₃NO₁₄S

CAS No.

441045-17-6

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (121.07 mM)

Ethanol : ≥ 100 mg/mL (121.07 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2107 mL 6.0533 mL 12.1065 mL
5 mM 0.2421 mL 1.2107 mL 2.4213 mL
10 mM 0.1211 mL 0.6053 mL 1.2107 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.03 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (3.03 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.03 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.52%

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Keywords:

EribulinB1939E7389ER-086526B 1939B-1939E 7389E-7389ER086526ER 086526Microtubule/TubulinApoptosismicrotubulemetastaticbreastcancerInhibitorinhibitorinhibit

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Eribulin mesylate
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