2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Eribulin mesylate (purity>99%, single impurity ≤ 0.15%)

Eribulin mesylate (purity>99%, single impurity ≤ 0.15%)  (Synonyms: B1939 mesylate (purity>99%, single impurity ≤ 0.15%); E7389 mesylate (purity>99%, single impurity ≤ 0.15%); ER-086526 mesylate (purity>99%, single impurity ≤ 0.15%))

Cat. No.: HY-13442C
Handling Instructions Technical Support

Eribulin (B1939; E7389; ER-086526) mesylate (purity>99%, single impurity ≤ 0.15%) is an inhibitor for microtubule. Eribulin mesylate (purity>99%, single impurity ≤ 0.15%) inhibits the proliferation of cancer cell LM8 and Dunn, inhibits the cell migration of LM8, arrests the cell cycle at G2/M phase, and induces apoptosis in LM8. Eribulin mesylate (purity>99%, single impurity ≤ 0.15%) exhibits antitumor efficacy in mouse model.

For research use only. We do not sell to patients.

Eribulin mesylate (purity>99%, single impurity ≤ 0.15%)

Eribulin mesylate (purity>99%, single impurity ≤ 0.15%) Chemical Structure

CAS No. : 441045-17-6

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Eribulin mesylate (purity>99%, single impurity ≤ 0.15%) Related Antibodies

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3 Publications Citing Use of MCE Eribulin mesylate (purity>99%, single impurity ≤ 0.15%)

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  • Purity & Documentation

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Description

Eribulin (B1939; E7389; ER-086526) mesylate (purity>99%, single impurity ≤ 0.15%) is an inhibitor for microtubule. Eribulin mesylate (purity>99%, single impurity ≤ 0.15%) inhibits the proliferation of cancer cell LM8 and Dunn, inhibits the cell migration of LM8, arrests the cell cycle at G2/M phase, and induces apoptosis in LM8. Eribulin mesylate (purity>99%, single impurity ≤ 0.15%) exhibits antitumor efficacy in mouse model[1].

In Vitro

Eribulin mesylate (1-100 nM; 72 h) (purity>99%, single impurity ≤ 0.15%) inhibits cells proliferation, with IC50s of 22.8 and 21.5 nM for LM8 and Dunn cells, respectively[1].
Eribulin mesylate (10-50 nM; 12-72 h) (purity>99%, single impurity ≤ 0.15%) increases early apoptosis significantly after 24 h treatment at the dose of 50 nM in LM8 cells[1].
Eribulin mesylate (10-50 nM; 12-72 h) (purity>99%, single impurity ≤ 0.15%) induces G2/M arrest by 12 h treatment with at the dose of 50 nM, but not by long-term treatment (72 h) with 10 nM in LM8 cells[1].
Eribulin mesylate (1-50 nM; 12 h) (purity>99%, single impurity ≤ 0.15%) does not induce senescence in LM8 cells[1].
Eribulin mesylate (1-10 nM; 16 h) (purity>99%, single impurity ≤ 0.15%) induces morphological change and suppresses cell migration in a low concentration in LM8 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Eribulin mesylate (purity>99%, single impurity ≤ 0.15%) Related Antibodies

Cell Proliferation Assay[1]

Cell Line: LM8 cells and Dunn cells
Concentration: 0, 1, 10, 100 nM
Incubation Time: 72 hours
Result: Inhibited cells proliferation in a dose-dependent manner.

Cell Proliferation Assay[1]

Cell Line: LM8 cells
Concentration: 0, 10, 50 nM
Incubation Time: 12, 24, 48, 72 hour
Result: Induced early apoptosis after 12 h at the concentration of 50 nM.
Not detected apoptosis at the concentration of 10 nM.

Cell Proliferation Assay[1]

Cell Line: LM8 cells
Concentration: 0, 10, 50 nM
Incubation Time: 12, 24, 48, 72 hour
Result: Induced G2/M arrest by 12 h treatment with 50 nM.
No G2/M arrest was induced by10 nM treatment.
In Vivo

Eribulin mesylate (1 mg/kg; i.v. once a week for 2 weeks) (purity>99%, single impurity ≤ 0.15%) reduces primary tumor growth and lung metastasis of osteosarcoma in mice[1].
Eribulin mesylate (1 mg/kg; once i.v.) (purity>99%, single impurity ≤ 0.15%) suppresses circulating tumor cells (CTC) appearance in the low-concentration phase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C3H/HeN mice (4-week-old) are injected LM8 cells[1] 1 mg/kg I.v. once a week for 2 weeks Suppressed primary tumor growth and induced apoptosis in tumor cells.
Reduced lung metastasis.
Dosage: 1 mg/kg
Administration: I.v. once a week for 2 weeks
Result: Suppressed primary tumor growth and induced apoptosis in tumor cells.
Reduced lung metastasis.
Clinical Trial
Molecular Weight

826.00

Formula

C41H63NO14S
CAS No.
SMILES

C=C1C[C@@](CC[C@@]2(C[C@@]3([H])O4)O[C@]([C@](O[C@](C5)([H])CC6)([H])[C@@]6([H])O7)([H])[C@@]4([H])[C@]7([H])[C@@]3([H])O2)([H])O[C@@]1([H])CC[C@](C[C@@H](C)C8=C)([H])O[C@]8([H])C[C@@](O[C@H](C[C@H](O)CN)[C@@H]9OC)([H])[C@]9([H])CC5=O.CS(=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Eribulin mesylate (purity>99%, single impurity ≤ 0.15%) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eribulin mesylate (purity>99%, single impurity ≤ 0.15%)441045-17-6B1939 mesylate (purity>99%, single impurity ≤ 0.15%) E7389 mesylate (purity>99%, single impurity ≤ 0.15%) ER-086526 mesylate (purity>99%, single impurity ≤ 0.15%)Microtubule/TubulinApoptosisLM8DunnInhibitorinhibitorinhibit

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