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Cabazitaxel

HY-15459

(XRP6258; RPR-116258A; taxoid XRP6258)

Cabazitaxel

Cabazitaxel Chemical Structure

Cabazitaxel(XRP6258; RPR-116258A) is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $97 In-stock
5 mg $60 In-stock
10 mg $105 In-stock
50 mg $250 In-stock
100 mg $350 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €95 In-stock
5 mg €59 In-stock
10 mg €103 In-stock
50 mg €245 In-stock
100 mg €343 In-stock
200 mg Get quote
500 mg Get quote

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Inquiry Information
Product name: Cabazitaxel
Cat. No.: HY-15459

Cabazitaxel Data Sheet

  • View current batch:

    Purity: 99.89%

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    DataSheet

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Related Compound Libraries

Biological Activity of Cabazitaxel

Cabazitaxel(XRP6258; RPR-116258A) is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.
IC50 Value:
Target: Microtubule/Tubulin
Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).

Chemical Information

M.Wt 835.93 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₄₅H₅₇NO₁₄
CAS No 183133-96-2
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.1963 mL 5.9814 mL 11.9627 mL
5 mM 0.2393 mL 1.1963 mL 2.3925 mL
10 mM 0.1196 mL 0.5981 mL 1.1963 mL

Clinical Information of Cabazitaxel

Product Name Sponsor Only Condition Start Date End Date Phase Last Change Date
Cabazitaxel Rheinisch-Westfalische Technische Hochschule Aachen (RWTH) Metastatic prostate cancer 31-JUL-13 31-AUG-18 Phase 2 30-SEP-13
Sarah Cannon Research Institute Metastatic breast cancer 30-NOV-13 31-MAR-16 Phase 2 25-NOV-13
Krankenhaus Nordwest Metastatic stomach cancer 30-SEP-13 Phase 2 17-OCT-13
University Hospital Birmingham NHS Foundation Trust Transitional cell carcinoma 31-JAN-13 31-DEC-15 Phase 3 11-SEP-13
Associació per a la Recerca Oncologica Transitional cell carcinoma 31-OCT-12 30-NOV-16 Phase 3 18-APR-13

References on Cabazitaxel

Inhibitor Kit

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