1. Cell Cycle/DNA Damage
    Cytoskeleton
    Apoptosis
  2. Microtubule/Tubulin
    Apoptosis
  3. Fosbretabulin disodium

Fosbretabulin disodium (Synonyms: CA 4DP; CA 4P; Combretastatin A4 disodium phosphate)

Cat. No.: HY-17449 Purity: 99.47%
Handling Instructions

Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 prodrug that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis.

For research use only. We do not sell to patients.

Fosbretabulin disodium Chemical Structure

Fosbretabulin disodium Chemical Structure

CAS No. : 168555-66-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in Water USD 99 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 99 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Fosbretabulin disodium (CA 4DP) is a tubulin destabilizing agent. Fosbretabulin disodium is the Combretastatin A4 prodrug that selectively targets endothelial cells, induces regression of nascent tumour neovessels, reduces tumour blood flow and causes central tumour necrosis[1][3].

IC50 & Target

tubulin[1]

In Vitro

Fosbretabulin disodium inhibits growth of leukemia P-388, pancreas BXPC-3, neuroblast SK-N-SH, thyroid SW1736, lung-NSC NCI-H460, prostate DU-145, an pharynx FADU, with EC50s of 0.0029, 0.23, 0.00025, 0.00061, 0.00035, 0.00072, and 0.00045 μg/mL, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fosbretabulin disodium (100 mg/kg; i.p.) increases the mean arterial blood pressure (MABP) at 1 and 6 h after administration and decreases the tumor blood flow in rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BD9 rats (7-9 weeks) bearing the s.c. implanted P22 tumor[3]
Dosage: 100 mg/kg
Administration: A single i.p. injections
Result: Significantly raised the MABP by about 30%, and reduced the heart rate at 1 h after administration.
Reduced the blood flow in the tumor.
Clinical Trial
Molecular Weight

440.29

Formula

C₁₈H₁₉Na₂O₈P

CAS No.
SMILES

COC1=C(OC)C(OC)=CC(/C=C\C2=CC=C(OC)C(OP(O[Na])(O[Na])=O)=C2)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 4.5 mg/mL (10.22 mM; Need ultrasonic and warming)

DMF : 1 mg/mL (2.27 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2712 mL 11.3562 mL 22.7123 mL
5 mM 0.4542 mL 2.2712 mL 4.5425 mL
10 mM 0.2271 mL 1.1356 mL 2.2712 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Fosbretabulin disodiumCA 4DP CA 4PCombretastatin A4 disodiumMicrotubule/TubulinApoptosistubulindestabilizingendothelianascenttumourneovesselsInhibitorinhibitorinhibit

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Product Name:
Fosbretabulin disodium
Cat. No.:
HY-17449
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