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Signaling Pathway

Docetaxel Trihydrate

HY-B0011A

Docetaxel Trihydrate

Docetaxel Trihydrate Chemical Structure

Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.

Docetaxel Trihydrate

CAS No.: 148408-66-6 Backordered

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100 mg $60 Backordered
200 mg $85 Backordered

Docetaxel

CAS No.: 114977-28-5 In-stock

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Product name: Docetaxel Trihydrate
Cat. No.: HY-B0011A

Docetaxel Trihydrate Data Sheet

  • Network Version

    DataSheet

Related Compound Libraries

Biological Activity of Docetaxel Trihydrate

Docetaxel trihydrate(Taxotere trihydrate), an analog of taxol, is an inhibitor of depolymerisation of microtubules through binding to stabilized microtubules.
IC50 Value:
Target: Microtubule/Tubulin
in vitro: IC50 concentrations (reducing survival by 50%) ranged from 0.13-3.3 ng/ml, with three neuroblastoma lines proving most sensitive and three breast and two colon carcinoma lines showing least sensitivity [1]. Docetaxel was shown to promote the assembly of microtubule protein without GTP in vitro, but no inhibitory effect on DNA, RNA and protein synthesis [2]. Gene expression changes induced by paclitaxel treatment were mainly enriched in actin cytoskeleton (ACTC1, MYL2 and MYH2), tyrosine-protein kinases (ERRB4, KIT and TIE1) and focal adhesion pathway (MYL2, IGF1 and FLT1), while the expression alterations responding to docetaxel were highly co-related to cell surface receptor linked signal transduction (SHH, DRD5 and ADM2), cytokine-cytokine receptor interaction (IL1A and IL6) and cell cycleregulation (CCNB1, CCNE2 and PCNA) [4].
in vivo:  The patients, between 15 and 80 years old with performance status (PS) of 0-2, received at least two cycles of docetaxel 60 mg m-2 intravenously at 3-4 week intervals [3]. Intestinal damage after repeated dosing of docetaxel (20 mg/kg) for 3 weeks was more severe at 14HALO than at 2HALO (hours after light on). The intestinal protein expressions of Wee1, phosphorylated CDK1, and cleaved Caspase-3 were higher in the 14HALO group than in the 2HALO group, while that of survivin was lower in the 14HALO group [5].
Toxicity: Twenty-five patients were enrolled. Overall, 13/25 (52 %, 95 % CI 34-70) completed 4 cycles, and 19/25 (76 %, 95 % CI 60-87) completed ≥3 cycles. Twenty of 25 patients (80 %) experienced a Grade 3 or 4 adverse event [6].

Chemical Information

M.Wt 861.93 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₄₃H₅₉NO₁₇
CAS No 148408-66-6
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.1602 mL 5.8009 mL 11.6019 mL
5 mM 0.2320 mL 1.1602 mL 2.3204 mL
10 mM 0.1160 mL 0.5801 mL 1.1602 mL

References on Docetaxel Trihydrate

Inhibitor Kit

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