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(DLS 10; NSC 376128; Dolastatin-10)
Dolastatin 10 Chemical Structure
|Product name: Dolastatin 10|
|Cat. No.: HY-15580|
Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly. Dolastatin and Dolastatin's analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE)
Target: Tubulin; ADCs
Dolastatin 10 consists of four amino acids (in order from the amino terminus: dolavaline, valine, dolaisoleucine, and dolaproine), three unique to D. auricularia, linked to an unusual primary amine (dolaphenine, probably derived from phenylalanine) at what would otherwise be its carboxyl terminus. Monomethylauristatin E (MMAE) is a synthetic dolastatin 10 derivative with pronounced activity and toxicity.
The anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E, a synthetic analog of the tubulin polymerization inhibitor dolastatin.
|M.Wt||785.09||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
10 mM in DMSO
|1 mg||5 mg||10 mg|
|1 mM||1.2737 mL||6.3687 mL||12.7374 mL|
|5 mM||0.2547 mL||1.2737 mL||2.5475 mL|
|10 mM||0.1274 mL||0.6369 mL||1.2737 mL|
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