1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    ADC Cytotoxin

Dolastatin 10 (Synonyms: DLS 10; NSC 376128)

Cat. No.: HY-15580 Purity: 99.83%
Data Sheet SDS Handling Instructions

Dolastatin 10 is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization.

For research use only. We do not sell to patients.
Dolastatin 10 Chemical Structure

Dolastatin 10 Chemical Structure

CAS No. : 110417-88-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $2461 In-stock
1 mg $522 In-stock
5 mg $1425 In-stock
10 mg   Get quote  
50 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Dolastatin 10 is a potent antimitotic peptide, isolated from the marine mollusk Dolabela auricularia, that inhibits tubulin polymerization.

IC50 & Target

Tubulin[1]

In Vitro

Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI50 values of 10−5-10−6 μg/mL (10−2-10−3 nM) against a similar minipanel of human cell lines[2]. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10[3].

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT00003677 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Pancreatic Cancer March 1999 Phase 2
NCT00003778 National Cancer Institute (NCI) Ovarian Cancer|Sarcoma April 1999 Phase 2
NCT00003557 University of Chicago|National Cancer Institute (NCI) Extrahepatic Bile Duct Cancer|Gallbladder Cancer|Liver Cancer January 1999 Phase 2
NCT00003914 Mayo Clinic|National Cancer Institute (NCI) Kidney Cancer August 1999 Phase 2
NCT00003693 M.D. Anderson Cancer Center|National Cancer Institute (NCI) Leukemia|Myelodysplastic Syndromes March 1999 Phase 1
NCT00003626 Barbara Ann Karmanos Cancer Institute|National Cancer Institute (NCI) Prostate Cancer October 1998 Phase 2
NCT00005579 University of Vermont|National Cancer Institute (NCI) Leukemia|Lymphoma June 1998 Phase 2
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References
Molecular Weight

785.09

Formula

C₄₂H₆₈N₆O₆S

CAS No.

110417-88-4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Dolastatin 10
Cat. No.:
HY-15580
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