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Signaling Pathway

Dolastatin 10

HY-15580

(DLS 10; NSC 376128; Dolastatin-10)

Dolastatin 10

Dolastatin 10 Chemical Structure

Dolastatin 10(DLS 10;NSC 376128) is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly; Dolastatin and Dolastatin's analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE).

Size Price Stock Quantity
10 mM * 1 mL in DMSO $2461 In-stock
1 mg $522 In-stock
5 mg $1425 In-stock
10 mg Get quote
50 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €2412 In-stock
1 mg €512 In-stock
5 mg €1397 In-stock
10 mg Get quote
50 mg Get quote

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Product name: Dolastatin 10
Cat. No.: HY-15580

Dolastatin 10 Data Sheet

  • View current batch:

    Purity: 98.44%

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    DataSheet

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    MSDS

    Pdf Version

    COA

Related Compound Libraries

Biological Activity of Dolastatin 10

Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly. Dolastatin and Dolastatin's analogs are the cytotoxic components in Antibody-drug conjugates design (eg. cAC10-vcMMAE)
IC50 Value:
Target: Tubulin; ADCs
Dolastatin 10 consists of four amino acids (in order from the amino terminus: dolavaline, valine, dolaisoleucine, and dolaproine), three unique to D. auricularia, linked to an unusual primary amine (dolaphenine, probably derived from phenylalanine) at what would otherwise be its carboxyl terminus. Monomethylauristatin E (MMAE) is a synthetic dolastatin 10 derivative with pronounced activity and toxicity.
The anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E, a synthetic analog of the tubulin polymerization inhibitor dolastatin.
 

Chemical Information

M.Wt 785.09 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₄₂H₆₈N₆O₆S
CAS No 110417-88-4
Solvent & Solubility

10 mM in DMSO

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.2737 mL 6.3687 mL 12.7374 mL
5 mM 0.2547 mL 1.2737 mL 2.5475 mL
10 mM 0.1274 mL 0.6369 mL 1.2737 mL

References on Dolastatin 10

Inhibitor Kit
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  • 2-Methoxyestradiol

    2-methoxyestradiol (2ME2; NSC-659853) is a natural metabolite of estrogen that is known to inhibit HIF-1 alpha with an IC50 of 0.71 (plusmn) 0.11 (mu)M for the inhibition of BPAEC migration.

  • 4'-Demethylepipodophyllotoxin

    4(acute)-Demethylepipodophyllotoxin(4(acute)-DMEP) is a key intermediate compound for the preparation of podophyllotoxin-type anti-cancer drugs; a potent inhibitor of microtubule assembly.

  • 7-Epi-10-oxo-docetaxel

    7-Epi-10-oxo-docetaxel (Docetaxel Impurity D) is a impurity of docetaxel detected by high performance liquid chromatography (HPLC).

  • 7-Epi-docetaxel

    7-Epi-10-oxo-docetaxel (Docetaxel Impurity C; 7-Epitaxotere) is a impurity of docetaxel.

  • 7-xylosyltaxol

    7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.

  • ABT-751

    ABT-751(E 7010) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 (mu)M in neuroblastoma and non-neuroblastoma cell lines, respectively.

  • alpha-Amanitin

    alpha-Amanitin is a potent inhibitor of DNA-dependent RNA polymerase II.

  • Auristatin E

    Auristatin E is a cytotoxic tubulin modifier with potent and selective antitumor activity; MMAE analog and cytotoxin in Antibody-drug conjugates.

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