1. Cell Cycle/DNA Damage Cytoskeleton Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin ADC Cytotoxin
  3. Dolastatin 10

Dolastatin 10  (Synonyms: DLS 10; NSC 376128)

Cat. No.: HY-15580 Purity: 98.11%
COA Handling Instructions

Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Dolastatin 10 Chemical Structure

Dolastatin 10 Chemical Structure

CAS No. : 110417-88-4

Size Price Stock Quantity
1 mg USD 260 In-stock
5 mg USD 650 In-stock
10 mg USD 980 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.

IC50 & Target



In Vitro

Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI50 values of 10−5-10−6 μg/mL (10−2-10−3 nM) against a similar minipanel of human cell lines[2]. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight







White to off-white

Structure Classification

Room temperature in continental US; may vary elsewhere.


Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (127.37 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2737 mL 6.3687 mL 12.7374 mL
5 mM 0.2547 mL 1.2737 mL 2.5475 mL
10 mM 0.1274 mL 0.6369 mL 1.2737 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 98.11%

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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