1. Cell Cycle/DNA Damage
    Cytoskeleton
    Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin
    ADC Cytotoxin
  3. Dolastatin 10

Dolastatin 10 (Synonyms: DLS 10; NSC 376128)

Cat. No.: HY-15580 Purity: 99.83%
Handling Instructions

Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Dolastatin 10 Chemical Structure

Dolastatin 10 Chemical Structure

CAS No. : 110417-88-4

Size Price Stock Quantity
1 mg USD 626 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1710 In-stock
Estimated Time of Arrival: December 31
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Description

Angiotensin II human is a vasoconstrictor that acts on the AT1 and the AT2 receptor.

IC50 & Target

Tubulin[1]

In Vitro

Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI50 values of 10−5-10−6 μg/mL (10−2-10−3 nM) against a similar minipanel of human cell lines[2]. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10[3].

Clinical Trial
Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

785.09

Formula

C₄₂H₆₈N₆O₆S

CAS No.

110417-88-4

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.83%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Dolastatin 10
Cat. No.:
HY-15580
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Dolastatin 10

Cat. No.: HY-15580