1. Cell Cycle/DNA Damage Cytoskeleton Antibody-drug Conjugate/ADC Related
  2. Microtubule/Tubulin ADC Cytotoxin
  3. Dolastatin 10

Dolastatin 10  (Synonyms: DLS 10; NSC 376128)

Cat. No.: HY-15580 Purity: 98.11%
COA Handling Instructions

Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Dolastatin 10 Chemical Structure

Dolastatin 10 Chemical Structure

CAS No. : 110417-88-4

Size Price Stock Quantity
1 mg USD 260 In-stock
5 mg USD 650 In-stock
10 mg USD 980 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.

IC50 & Target

Auristatin

 

In Vitro

Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI50 values of 10−5-10−6 μg/mL (10−2-10−3 nM) against a similar minipanel of human cell lines[2]. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

785.09

Formula

C42H68N6O6S

CAS No.
Appearance

Solid

Color

White to off-white

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (127.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2737 mL 6.3687 mL 12.7374 mL
5 mM 0.2547 mL 1.2737 mL 2.5475 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.11%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2737 mL 6.3687 mL 12.7374 mL 31.8435 mL
5 mM 0.2547 mL 1.2737 mL 2.5475 mL 6.3687 mL
10 mM 0.1274 mL 0.6369 mL 1.2737 mL 3.1843 mL
15 mM 0.0849 mL 0.4246 mL 0.8492 mL 2.1229 mL
20 mM 0.0637 mL 0.3184 mL 0.6369 mL 1.5922 mL
25 mM 0.0509 mL 0.2547 mL 0.5095 mL 1.2737 mL
30 mM 0.0425 mL 0.2123 mL 0.4246 mL 1.0614 mL
40 mM 0.0318 mL 0.1592 mL 0.3184 mL 0.7961 mL
50 mM 0.0255 mL 0.1274 mL 0.2547 mL 0.6369 mL
60 mM 0.0212 mL 0.1061 mL 0.2123 mL 0.5307 mL
80 mM 0.0159 mL 0.0796 mL 0.1592 mL 0.3980 mL
100 mM 0.0127 mL 0.0637 mL 0.1274 mL 0.3184 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Dolastatin 10
Cat. No.:
HY-15580
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