Synthesis of Dolastatin 15 mimetic peptoids

  • Bioorg Med Chem Lett. 1998 Feb 17;8(4):385-8. doi: 10.1016/s0960-894x(98)00034-1.
J Schmitt  1 ,  M Bernd ,  B Kutscher ,  H Kessler
Affiliations
  • 1. Institut für Organische Chemie und Biochemie Technischen Universität München, Garching, Germany.
PMID: 9871690 DOI: 10.1016/s0960-894x(98)00034-1
Abstract

Eight peptoids have been synthesized as peptidomimetics of the cytostatic Dolastatin 15, a depsipeptide isolated from the Indian sea hare Dolabella auricularia. The compounds have been tested against several human Cancer cell lines and did not show any cytostatic properties.