Successful, we will reply to you quickly.OK
Please select the quantity.OK
Your message is being sent, please wait.Close
Send mail failed, please send again!Close
Products are for research use only. Not for human use. We do not sell to patients.
(SQ 34676; BMS 200475; SQ34676; BMS200475; SQ-34676; BMS-200475)
Entecavir monohydrate Chemical Structure
|Product name: Entecavir monohydrate|
|Cat. No.: HY-13623A|
Entecavir monohydrate(SQ 34676; BMS 200475) is a nucleoside analog that inhibits reverse transcription; entecavir is used to treat chronic hepatitis B.
Entecavir monohydrate is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir monohydrate is a nucleoside analog (more specifically, a guanine analogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process. Entecavir monohydrate is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). Entecavir monohydrate is also indicated for the treatment of chronic hepatitis B in adults with HIV/AIDS infection. However, Entecavir is not active against HIV .
Entecavir cumulative urinary excretion was statistically significant at 45 and 60min. CLR(4°C), CLR(37°C Control) and CLR(37°C Experiment) were 12.6, 27.6 and 36 (ml/min/kg), respectively. CLTS and TR rate (for PEPT2) were 25.3 and 9.4 (ml/min/kg). In vivo, the cumulative urinary excretion of entecavir had statistical significance at 3 and 4h with CLR(Control) and CLR(Experiment) values of 31 and 42 (ml/min/kg), respectively. The CLTS and TR rate (for PEPT2) were 32 and 11.6 (ml/min/kg), respectively .
indications: Hepatitis B virus infection
FDA Approved Date: March 2005
|M.Wt||295.29||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: ≥ 32 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||3.3865 mL||16.9325 mL||33.8650 mL|
|5 mM||0.6773 mL||3.3865 mL||6.7730 mL|
|10 mM||0.3387 mL||1.6933 mL||3.3865 mL|
. Hagiwara S, et al. Impact of peginterferon alpha-2b and entecavir hydrate combination therapy on persistent viral suppression in patients with chronic hepatitis B. J Med Virol. 2013 Jun;85(6):987-95.
Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.
Bicyclol(SY 801) is a anti-hepatitis drug.
Clevudine is an antiviral drug for the treatment of hepatitis B.
Lagociclovir(MIV-210) is a prodrug of 3(acute)-fluoro-2(acute),3(acute)-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV.
Merimepodiba(VX-497) is a novel noncompetitive inhibitor of IMPDH(Inosine monophosphate dehydrogenase).
Oxethazaine is a topical anesthetic, in preventing acid-induced esophageal pain.
Telbivudine, a specific inhibitor of hepatitis B virus (HBV) replication, is an antiviral drug used in the treatment of hepatitis B infection.