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Products are for research use only. Not for human use. We do not sell to patients.
(SQ 34676; BMS 200475; SQ34676; BMS200475; SQ-34676; BMS-200475)
Entecavir monohydrate Chemical Structure
|Product name: Entecavir monohydrate|
|Cat. No.: HY-13623A|
Entecavir monohydrate(SQ 34676; BMS 200475) is a nucleoside analog that inhibits reverse transcription; entecavir is used to treat chronic hepatitis B.
Entecavir monohydrate is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir monohydrate is a nucleoside analog (more specifically, a guanine analogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process. Entecavir monohydrate is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). Entecavir monohydrate is also indicated for the treatment of chronic hepatitis B in adults with HIV/AIDS infection. However, Entecavir is not active against HIV .
Entecavir cumulative urinary excretion was statistically significant at 45 and 60min. CLR(4°C), CLR(37°C Control) and CLR(37°C Experiment) were 12.6, 27.6 and 36 (ml/min/kg), respectively. CLTS and TR rate (for PEPT2) were 25.3 and 9.4 (ml/min/kg). In vivo, the cumulative urinary excretion of entecavir had statistical significance at 3 and 4h with CLR(Control) and CLR(Experiment) values of 31 and 42 (ml/min/kg), respectively. The CLTS and TR rate (for PEPT2) were 32 and 11.6 (ml/min/kg), respectively .
indications: Hepatitis B virus infection
FDA Approved Date: March 2005
|M.Wt||295.29||Storage||Please store the product under the recommended conditions in the Certificate of Analysis.|
|Solvent & Solubility||
DMSO: ≥ 32 mg/mL
|1 mg||5 mg||10 mg|
|1 mM||3.3865 mL||16.9325 mL||33.8650 mL|
|5 mM||0.6773 mL||3.3865 mL||6.7730 mL|
|10 mM||0.3387 mL||1.6933 mL||3.3865 mL|
. Hagiwara S, et al. Impact of peginterferon alpha-2b and entecavir hydrate combination therapy on persistent viral suppression in patients with chronic hepatitis B. J Med Virol. 2013 Jun;85(6):987-95.
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