Successful, we will reply to you quickly.

OK

Please select the quantity.

OK

Your message is being sent, please wait.

Close

test

Close

Send mail failed, please send again!

Close

Products are for research use only. Not for human use. We do not sell to patients.

Signaling Pathway

Entecavir monohydrate

HY-13623A

(SQ 34676; BMS 200475; SQ34676; BMS200475; SQ-34676; BMS-200475)

Entecavir monohydrate

Entecavir monohydrate Chemical Structure

Entecavir monohydrate(SQ 34676; BMS 200475) is a nucleoside analog that inhibits reverse transcription; entecavir is used to treat chronic hepatitis B.

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
5 mg $50 In-stock
10 mg $90 In-stock
50 mg $189 In-stock
100 mg $336 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO €54 In-stock
5 mg €49 In-stock
10 mg €88 In-stock
50 mg €185 In-stock
100 mg €329 In-stock
200 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Bulk Inquiry

Inquiry Information
Product name: Entecavir monohydrate
Cat. No.: HY-13623A

Entecavir monohydrate Data Sheet

  • View current batch:

    Purity: 99.66%

  • Network Version

    DataSheet

    Pdf Version Network Version

    MSDS

Related Compound Libraries

Biological Activity of Entecavir monohydrate

Entecavir monohydrate(SQ 34676; BMS 200475) is a nucleoside analog that inhibits reverse transcription; entecavir is used to treat chronic hepatitis B.
IC50 value:
Target: HBV
Entecavir monohydrate is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir monohydrate is a nucleoside analog (more specifically, a guanine analogue) that inhibits reverse transcription, DNA replication and transcription in the viral replication process. Entecavir monohydrate is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). Entecavir monohydrate is also indicated for the treatment of chronic hepatitis B in adults with HIV/AIDS infection. However, Entecavir is not active against HIV [1].
Entecavir cumulative urinary excretion was statistically significant at 45 and 60min. CLR(4°C), CLR(37°C Control) and CLR(37°C Experiment) were 12.6, 27.6 and 36 (ml/min/kg), respectively. CLTS and TR rate (for PEPT2) were 25.3 and 9.4 (ml/min/kg). In vivo, the cumulative urinary excretion of entecavir had statistical significance at 3 and 4h with CLR(Control) and CLR(Experiment) values of 31 and 42 (ml/min/kg), respectively. The CLTS and TR rate (for PEPT2) were 32 and 11.6 (ml/min/kg), respectively [2].
indications: Hepatitis B virus infection
FDA Approved Date:   March 2005


 

Chemical Information

M.Wt 295.29 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C₁₂H₁₇N₅O₄
CAS No 209216-23-9
Solvent & Solubility

DMSO: ≥ 32 mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 3.3865 mL 16.9325 mL 33.8650 mL
5 mM 0.6773 mL 3.3865 mL 6.7730 mL
10 mM 0.3387 mL 1.6933 mL 3.3865 mL

References on Entecavir monohydrate

Other Forms

Inhibitor Kit

Related HBV Products

  • Adefovir dipivoxil

    Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body.

  • Bicyclol

    Bicyclol(SY 801) is a anti-hepatitis drug.

  • Clevudine

    Clevudine is an antiviral drug for the treatment of hepatitis B.

  • Lagociclovir

    Lagociclovir(MIV-210) is a prodrug of 3(acute)-fluoro-2(acute),3(acute)-dideoxyguanosine with high oral bioavailability in humans and potent activity against HBV.

  • Merimepodib

    Merimepodiba(VX-497) is a novel noncompetitive inhibitor of IMPDH(Inosine monophosphate dehydrogenase).

  • Osalmid

    Osalmid is a ribonucleotide reductase small subunit M2 (RRM2) targeting compound; suppresses ribonucleotide reductase activity with an IC50 of 8.23 (mu)M.

  • Oxethazaine

    Oxethazaine is a topical anesthetic, in preventing acid-induced esophageal pain.

  • Telbivudine

    Telbivudine, a specific inhibitor of hepatitis B virus (HBV) replication, is an antiviral drug used in the treatment of hepatitis B infection.