1. Metabolic Enzyme/Protease
  2. Dipeptidyl Peptidase
  3. Diprotin A TFA

Diprotin A TFA (Synonyms: Ile-Pro-Pro (TFA))

Cat. No.: HY-111174A Purity: 98.80%
Handling Instructions

Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

For research use only. We do not sell to patients.

Diprotin A TFA Chemical Structure

Diprotin A TFA Chemical Structure

CAS No. : 209248-71-5

Size Price Stock Quantity
10 mM * 1 mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
25 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 190 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).

IC50 & Target

DPP-IV[1].

In Vitro

Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1].

In Vivo

In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1].

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 77.5 mg/mL (170.15 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1955 mL 10.9777 mL 21.9553 mL
5 mM 0.4391 mL 2.1955 mL 4.3911 mL
10 mM 0.2196 mL 1.0978 mL 2.1955 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

455.47

Formula

C₁₉H₃₂F₃N₃O₆

CAS No.

209248-71-5

SMILES

CC[[email protected]](C)[[email protected]@H](C(O)=O)NC([[email protected]]1N(C([[email protected]]([[email protected]@H](C)CC)N)=O)CCC1)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Diprotin A TFA
Cat. No.:
HY-111174A
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Diprotin A TFA

Cat. No.: HY-111174A