2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Epigenetics
  4. HDAC
  5. HDAC Isoform
  6. HDAC Degrader

HDAC Degrader

HDAC Degraders (15):

Cat. No. Product Name Effect Purity
  • HY-132998
    HDAC6 degrader-1
    		Degrader 99.58%
    HDAC6 degrader-1 is the PROTAC degrader for HDAC6 with a DC50 of 3.8 nM in cell MM.1S.
  • HY-171140
    PROTAC HDAC6 degrader 3
    		Degrader 99.81%
    PROTAC HDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader for HDAC6 with an IC50 of 686 nM and a DC50 of 171 nM. PROTAC HDAC6 degrader 3 promotes the acetylation of α-tubulin. (Pink: ligand for target protein (HY-171141); Blue: ligand for E3 ligase VHL (HY-150803))
  • HY-174444A
    PROTAC HDAC degrader-2 TFA
    		Degrader
    PROTAC HDAC degrader-2 TFA is the trifluoroacetate salt of PROTAC HDAC degrader-2. PROTAC HDAC degrader-2 is a selective IIb HDACs PROTAC degrader, with DC50s of 13 nM for HDAC6, 29 nM for HDAC10, respectively. PROTAC HDAC degrader-2 exhibits low cytotoxicity against hematological and solid cancer cell lines. PROTAC HDAC degrader-2 can be used for the chemical knockdown of class IIb HDACs.
  • HY-168863
    FF2049
    		Degrader
    FF2049 is a selective HDAC PROTAC degrader (DC50 = 257 nM for HDAC1). FF2049 promotes ubiquitination and degradation of HDAC. FF2049 promotes Apoptosis. FF2049 can be used for the research of hematological and solid cancer.
  • HY-174408
    HDAC6 ligand-5
    		Degrader
    HDAC6 ligand-5 is a binding ligand of HDAC6 and can be used to synthesize PROTACs such as PROTAC HDAC6 degrader 5.
  • HY-163920
    PROTAC HDAC8 Degrader-1
    		Degrader
    Degrader-1 (compound Z16) is a potent and selective HDAC8 PROTAC degrader with an DC50 of 0.27 nM in A549 cells.
  • HY-174409
    HDAC6 ligand-Linker Conjugate 1
    		Degrader
    HDAC6 ligand-linker conjugate 1 is a conjugate of HDAC6 ligand and linker, which can be used to synthesize PROTACs such as PROTAC HDAC6 degrader 5 (HY-174401).
  • HY-177776
    HDAC-IN-97
    		Degrader
    HDAC-IN-97 is a PROTAC HDAC6 degrader-6that can be used for synthesis of PROTACs, such as HDAC6 degrader-6 (HY-177758). HDAC6 degrader-6 is a potent HDAC6 PROTAC degrader with anticancer activity.
  • HY-157216
    HDAC1 Degrader-1
    		Degrader
    HDAC1 Degrader-1 (compound 1a) is an HDAC1 degrader with anticancer activity. HDAC1 Degrader-1 significantly reduces HDAC1 levels in MM.1S multiple myeloma cells.
  • HY-163845
    YX862
    		Degrader
    YX862 is a selective HDAC8 PROTAC degrader and induces the degradation of HDAC8 with maximum degradation ＞ 95% at 250 nM in MDA-MB-231 cells.
  • HY-155398
    PRO-HD3
    		Degrader
    PRO-HD3 is a cell-specific, PROTAC-based HDAC6 degrader.
  • HY-155397
    PRO-HD2
    		Degrader
    PRO-HD2 is a cell-specific, PROTAC-based HDAC6 degrader.
  • HY-155396
    PRO-HD1
    		Degrader
    PRO-HD1 is a PROTAC HDAC6 degrader. PRO-HD1 degrades HDAC6 in A549 cells, and inhibits proliferation of Jurkat cells (IC50: 5.8 μM).
  • HY-176207
    HDAC degrader-1
    		Degrader
    HDAC6 degrader-6 (compound 10c) is a ByeTAC protein degrader targeting HDAC6, with IC50 values of 0.034 μM, 0.166 μM, 0.703 μM, and 0.293 μM for HDAC6, HDAC1, HDAC2, and HDAC3, respectively. HDAC6 degrader-6 induces cell apoptosis and can be used for the study of multiple myeloma(Blue: USP14 ligand HY-159808; Pink: HDAC ligand HY-176209; Black: linker HY-W016871)
  • HY-182051
    HDAC3 degrader-2
    		Degrader
    HDAC3 degrader-2 is a selective HDAC3 degrader. HDAC3 degrader-2 inhibits the activation of the NLRP3 inflammasome by degrading HDAC3, thereby reducing the maturation of IL-1β and caspase-1. HDAC3 degrader-2 exhibits anti-inflammatory activity. HDAC3 degrader-2 can be used in research related to endotoxin shock, colitis and gouty arthritis.