3110847-73-6
Chemical Structure
HDAC3 degrader-2
- CAS No.: 3110847-73-6
- Formula:C54H70N6O5
- Molecular Weight:883.17
InChIKey: AJXOYXWJTBHKHN-FFEZMBHASA-N
SMILES: C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@@](C)(C4)C(N5CCN(C6=CC=C(C=C6)NC(CCCCCC(NC7=C(C=CC=C7)N)=O)=O)CC5)=O)C)=CC([C@]1([H])[C@@]8([C@@](C(C)(C(C(C#N)=C8)=O)C)([H])CC2)C)=O)C
Biological Activity: HDAC3 degrader-2 is a selective HDAC3 degrader. HDAC3 degrader-2 inhibits the activation of the NLRP3 inflammasome by degrading HDAC3, thereby reducing the maturation of IL-1β and caspase-1. HDAC3 degrader-2 exhibits anti-inflammatory activity. HDAC3 degrader-2 can be used in research related to endotoxin shock, colitis and gouty arthritis[1].
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HDAC3 degrader-2 | HDAC3 degrader-2 is a selective HDAC3 degrader. HDAC3 degrader-2 inhibits the activation of the NLRP3 inflammasome by degrading HDAC3, thereby reducing the maturation of IL-1β and caspase-1. HDAC3 degrader-2 exhibits anti-inflammatory activity. HDAC3 degrader-2 can be used in research related to endotoxin shock, colitis and gouty arthritis. | |||||||||||||||||||||
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