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Art. -Nr.: HY-163845

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YX862

YX862 is a selective HDAC8 PROTAC degrader and induces the degradation of HDAC8 with maximum degradation ＞ 95% at 250 nM in MDA-MB-231 cells.
(Pink: HDAC8 ligand (HY-163846); Blue: VHL ligand (HY-112078); Black: linker (HY-W007700)).

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CAS. Nr.: 3092219-09-2
Formel: C₄₈H₇₂N₈O₅S
Molecular Weight:873.20

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

YX862 Chemical Structure

CAS. Nr.: 3092219-09-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

YX862 is a selective HDAC8 PROTAC degrader and induces the degradation of HDAC8 with maximum degradation ＞ 95% at 250 nM in MDA-MB-231 cells^[1]. (Pink: HDAC8 ligand (HY-163846); Blue: VHL ligand (HY-112078); Black: linker (HY-W007700)).

Alle PROTACs Isoform-spezifische Produkte anzeigen :

Alle HDAC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
DOHH-2	IC₅₀	0.89 μM Compound: 38; YX862	Antiproliferative activity against human DOHH-2 cells assessed as cell viability measured after 72 hrs by Alamar Blue Assay Antiproliferative activity against human DOHH-2 cells assessed as cell viability measured after 72 hrs by Alamar Blue Assay	[PMID: 38949959]
SU-DHL-2	IC₅₀	0.72 μM Compound: 38; YX862	Antiproliferative activity against human SU-DHL-2 cells assessed as cell viability measured after 72 hrs by Alamar Blue Assay Antiproliferative activity against human SU-DHL-2 cells assessed as cell viability measured after 72 hrs by Alamar Blue Assay	[PMID: 38949959]

Chemical Information

CAS. Nr. 3092219-09-2
Molecular Weight 873.20
Formel C₄₈H₇₂N₈O₅S
SMILES

O=C([C@@H](NC(CCCCCCCN1CCN(C2=CC=C(C=C2)C(NNCCCCCC)=O)CC1)=O)C(C)(C)C)N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C=C4)C5=C(N=CS5)C)C)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Xiao Y, et al. Discovery of a Highly Potent and Selective HDAC8 Degrader: Advancing the Functional Understanding and Therapeutic Potential of HDAC8. J Med Chem. 2024 Jul 1. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
Chemical Information
Reinheit & Dokumentation
Verweise

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YX862

Alle PROTACs Isoform-spezifische Produkte anzeigen

Alle HDAC Isoform-spezifische Produkte anzeigen