YX862
YX862 is a selective HDAC8 PROTAC degrader and induces the degradation of HDAC8 with maximum degradation ＞ 95% at 250 nM in MDA-MB-231 cells.
(Pink: HDAC8 ligand (HY-163846); Blue: VHL ligand (HY-112078); Black: linker (HY-W007700)).
For research use only. We do not sell to patients.
- CAS No.: 3092219-09-2
- Formula: C48H72N8O5S
- Molecular Weight:873.20
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DOHH-2 | IC50 |
0.89 μM
Compound: 38; YX862
|
Antiproliferative activity against human DOHH-2 cells assessed as cell viability measured after 72 hrs by Alamar Blue Assay
Antiproliferative activity against human DOHH-2 cells assessed as cell viability measured after 72 hrs by Alamar Blue Assay
|
[PMID: 38949959] |
| SU-DHL-2 | IC50 |
0.72 μM
Compound: 38; YX862
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Antiproliferative activity against human SU-DHL-2 cells assessed as cell viability measured after 72 hrs by Alamar Blue Assay
Antiproliferative activity against human SU-DHL-2 cells assessed as cell viability measured after 72 hrs by Alamar Blue Assay
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[PMID: 38949959] |
Chemical Information
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CAS No. 3092219-09-2
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Molecular Weight 873.20
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Formula C48H72N8O5S
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SMILES
O=C([C@@H](NC(CCCCCCCN1CCN(C2=CC=C(C=C2)C(NNCCCCCC)=O)CC1)=O)C(C)(C)C)N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=CC=C(C=C4)C5=C(N=CS5)C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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