1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. MC1568

MC1568 

Cat. No.: HY-16914 Purity: 98.02%
Handling Instructions

MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor, used for cancer research.

For research use only. We do not sell to patients.

MC1568 Chemical Structure

MC1568 Chemical Structure

CAS No. : 852475-26-4

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg USD 336 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    MC1568 purchased from MCE. Usage Cited in: J Cell Physiol. 2018 Jan;233(1):673-687.

    The morphology of primary neurons treated with MC1568 or LMK235 is analyzed after staining for Tuj1. Scale bar, 200 μm. Inhibition of HDAC5 activity promotes neurite elongation of primary neurons.
    • Biological Activity

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    • References

    Description

    MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor, used for cancer research.

    IC50 & Target[1]

    HDAC

     

    In Vitro

    MC1568 arrests myogenesis by decreasing myocyte enhancer factor 2D (MEF2D) expression, by stabilizing the HDAC4–HDAC3–MEF2D complex, and paradoxically, by inhibiting differentiation-induced MEF2D acetylation[1]. MC1568 and MC1575 inhibits IL-8 levels and cell proliferation in either unstimulated or PMA-stimulated melanoma cells. They acts by suppressing c-Jun binding to the IL-8 promoter, recruitment of histones 3 and 4, RNA polymerase II and TFIIB to the c-Jun promoter, and c-Jun expression[2]. MC1568 interferes with the RAR- and PPARγ-mediated differentiation-inducing signaling pathways. In F9 cells, this inhibitor specifically blocks endodermal differentiation. In 3T3-L1 cells, MC1568 attenuates PPARγ-induced adipogenesis[3].

    In Vivo

    MC1568 shows an apparent tissue-selective HDAC inhibition. In skeletal muscle and heart, MC1568 inhibits the activity of HDAC4 and HDAC5 without affecting HDAC3 activity, thereby leaving MEF2–HDAC complexes in a repressed state[1]. MC1568 increases mortality and lesion volume and did not improve functional outcome. In addition, MC1568 decreases microtubule associated protein 2, phosphorylated neurofilament heavy chain and myelin basic protein immunoreactivity in the periinfarct cortex[4].

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 18.5 mg/mL (58.86 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.1816 mL 15.9079 mL 31.8157 mL
    5 mM 0.6363 mL 3.1816 mL 6.3631 mL
    10 mM 0.3182 mL 1.5908 mL 3.1816 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Cell Assay
    [2]

    For proliferation studies, 15 ×103 cells are seeded onto 24-well plates in RPMI-1640 medium supplemented with 10% heat-inactivated fetal bovine serum, 3 mM L-glutamine, 2% penicillin/streptomycin. After 24 h, untreated or HDACis-treated cells are incubated with either vehicle alone or PMA (50 ng/mL) for 6 h, and cell proliferation is evaluated by MTT assay and by cell number counting[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Administration
    [4]

    Adult male Wistar rats (n=15-17/group) are subjected to 2 h MCAO and orally gavaged with MC1568 (a selective class IIa HDAC inhibitor), SAHA (a non-selective HDAC inhibitor), or vehicle-control for 7 days starting 24 h after MCAO. A battery of behavioral tests is performed. Lesion volume measurement and immunohistochemistry are performed 28 days after MCAO[4]

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References
    Molecular Weight

    314.31

    Formula

    C₁₇H₁₅FN₂O₃

    CAS No.

    852475-26-4

    SMILES

    O=C(NO)/C=C/C1=CC=C(/C=C/C(C2=CC=CC(F)=C2)=O)N1C

    Shipping

    Room temperature in continental US; may vary elsewhere

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    Product Name:
    MC1568
    Cat. No.:
    HY-16914
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    Cat. No.: HY-16914