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Sodium 4-phenylbutyrate

(Synonyms: 4-PBA sodium; 4-Phenylbutyric acid sodium; Benzenebutyric acid sodium)
259 Cited Publications
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Based on 259 publication(s) in Google Scholar

Sodium 4-phenylbutyrate (4-PBA sodium) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

For research use only. We do not sell to patients.

  • Purity: 99.96%
  • CAS No.: 1716-12-7
  • Formula: C10H11NaO2
  • Molecular Weight:186.18
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Sodium 4-phenylbutyrate Chemical Structure
    Sodium 4-phenylbutyrate Chemical Structure
  • Experimental Validation Results for Sodium 4-phenylbutyrate
  • Experimental Validation Results for Sodium 4-phenylbutyrate
  • Experimental Validation Results for Sodium 4-phenylbutyrate
  • Experimental Validation Results for Sodium 4-phenylbutyrate
  • Experimental Validation Results for Sodium 4-phenylbutyrate
  • Experimental Validation Results for Sodium 4-phenylbutyrate
CAS No.: 1716-12-7
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  • Sodium 4-phenylbutyrate Chemical Structure
    Sodium 4-phenylbutyrate Chemical Structure
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    Sodium 4-phenylbutyrate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 29;16(1):8074. [Abstract]

    Customer Validation
     Western blot of the protein expression of ATF4, CHOP and the osteogenic marker BMP2 in the aortas from the male mice subjected to VitD3-induced vascular calcification, with or without treatment of 4PBA (20 mg/kg/day, ip).

  • 1/16

    Sodium 4-phenylbutyrate purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Nov;26(11):1892-1902. [Abstract]

    Customer Validation
     Percentages and numbers of CD45.1+CD8+ OT-I Teff cells in the spleens of mice treated with 4PBA (200 mg/kg, ip) or PBS (n = 8 mice per group).

  • 1/16

    Sodium 4-phenylbutyrate purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Apr 14:27:257-270. [Abstract]

    Customer Validation
     The protein levels of key molecules of ER stress and apoptosis in HG-induced fibroblasts after NET (1000 ng/mL, 24 h) treatment with or without pre-incubation for 1.5 h with 4-PBA (5 μM) or DNase I (2 U/mL).

  • 1/16

    Sodium 4-phenylbutyrate purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Apr 14:27:257-270. [Abstract]

    Customer Validation
     Edu assays were used to assess the proliferation of HG-induced fibroblasts after 24 hours of treatment with 4-PBA (5 μM) or DNase I (2 U/mL). Edu, red;DAPI, blue.

  • 1/16

    Sodium 4-phenylbutyrate purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2023 Apr 14:27:257-270. [Abstract]

    Customer Validation
     Migration ability of HG-induced fibroblasts was analyzed by transwell migration assay following the indicated treatment with 4-PBA (5 μM) or DNase I (2 U/mL) for 24 h.

  • 1/16

    Sodium 4-phenylbutyrate purchased from MedChemExpress. Usage Cited in: Autophagy. 2021 Nov;17(11):3592-3606. [Abstract]

    Customer Validation
     Cells are treated with 20 μM Cannabidiol for 24 h with or without pretreatment with 4-PBA (1 mM for 30 min); expression levels of ER stress and mitophagy related proteins are analyzed by western blotting.

  • Sodium 4-phenylbutyrate