2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. G194-0712

G194-0712 is a selective histone deacetylase 5 (HDAC5) activator with an EC50 of 7.96 μM and a Kd of 2.53 μM. G194-0712 restores ACTN4-K417 deacetylation and nuclear import, and increases CSTA expression. G194-0712 accelerates wound closure in chronic wound models, reducing wound area and epithelial gap. G194-0712 can be used for the research of chronic skin wounds, such as diabetic wounds, ischemic wounds, radiation injury wounds.

For research use only. We do not sell to patients.

G194-0712

G194-0712 Chemical Structure

CAS No. : 1029737-28-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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G194-0712 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

G194-0712 is a selective histone deacetylase 5 (HDAC5) activator with an EC50 of 7.96 μM and a Kd of 2.53 μM. G194-0712 restores ACTN4-K417 deacetylation and nuclear import, and increases CSTA expression. G194-0712 accelerates wound closure in chronic wound models, reducing wound area and epithelial gap. G194-0712 can be used for the research of chronic skin wounds, such as diabetic wounds, ischemic wounds, radiation injury wounds[1].

IC50 & Target[1]

HDAC5

7.96 μM (EC50)

HDAC5

2.53 μM (Kd)

In Vitro

G194-0712 shows EC50 values of 107.2, 100.4 and 111.5 μM for HDAC4, HDAC7 and HDAC9[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

G194-0712 Related Antibodies
In Vivo

G194-0712 (25 μM; topical application) accelerates diabetic wound healing in C57BLKS/J-db/db mice, ischemic wound healing and irradiated wound healing in C57BL/6J mice by reinstating ACTN4-K417 deacetylation, nuclear import, and CSTA expression, leading to reduced wound area and epithelial gap in and reduced wound area[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BLKS/J-db/db (male, 8 weeks old, chronic wound model); C57BL/6J mice (male, 8 weeks old)[1]
Dosage: 25 μM
Administration: Topical application
Result: Reinstated ACTN4-K417 deacetylation and nuclear import.
Increased CSTA expression and reduced wound area at PODs 5, 9, 14, and 18.
Decreased epithelial gap.
Molecular Weight

353.85

Formula

C20H20ClN3O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C1=CC=C(C=C1)N2C=CN=C(C2=O)NCC3=CC=CC=C3Cl)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (28.26 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8261 mL 14.1303 mL 28.2606 mL
5 mM 0.5652 mL 2.8261 mL 5.6521 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8261 mL 14.1303 mL 28.2606 mL 70.6514 mL
5 mM 0.5652 mL 2.8261 mL 5.6521 mL 14.1303 mL
10 mM 0.2826 mL 1.4130 mL 2.8261 mL 7.0651 mL
15 mM 0.1884 mL 0.9420 mL 1.8840 mL 4.7101 mL
20 mM 0.1413 mL 0.7065 mL 1.4130 mL 3.5326 mL
25 mM 0.1130 mL 0.5652 mL 1.1304 mL 2.8261 mL
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G194-0712 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G194-07121029737-28-7HDACHistone deacetylasesHDAC5Histone deacetylase 5CSTAACTN4-K417diabetic woundsradiation injury woundsC57BLKS/J-db/dbchronic skin woundsischemic woundsInhibitorinhibitorinhibit

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