2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. G194-0712

G194-0712 is a selective histone deacetylase 5 (HDAC5) activator with an EC50 of 7.96 μM and a Kd of 2.53 μM. G194-0712 restores ACTN4-K417 deacetylation and nuclear import, and increases CSTA expression. G194-0712 accelerates wound closure in chronic wound models, reducing wound area and epithelial gap. G194-0712 can be used for the research of chronic skin wounds, such as diabetic wounds, ischemic wounds, radiation injury wounds.

For research use only. We do not sell to patients.

G194-0712

G194-0712 Chemical Structure

CAS No. : 1029737-28-7

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G194-0712 Related Antibodies

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Description

G194-0712 is a selective histone deacetylase 5 (HDAC5) activator with an EC50 of 7.96 μM and a Kd of 2.53 μM. G194-0712 restores ACTN4-K417 deacetylation and nuclear import, and increases CSTA expression. G194-0712 accelerates wound closure in chronic wound models, reducing wound area and epithelial gap. G194-0712 can be used for the research of chronic skin wounds, such as diabetic wounds, ischemic wounds, radiation injury wounds[1].

IC50 & Target[1]

HDAC5

7.96 μM (EC50)

HDAC5

2.53 μM (Kd)

In Vitro

G194-0712 shows EC50 values of 107.2, 100.4 and 111.5 μM for HDAC4, HDAC7 and HDAC9[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

G194-0712 Related Antibodies
In Vivo

G194-0712 (25 μM; topical application) accelerates diabetic wound healing in C57BLKS/J-db/db mice, ischemic wound healing and irradiated wound healing in C57BL/6J mice by reinstating ACTN4-K417 deacetylation, nuclear import, and CSTA expression, leading to reduced wound area and epithelial gap in and reduced wound area[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BLKS/J-db/db (male, 8 weeks old, chronic wound model); C57BL/6J mice (male, 8 weeks old)[1]
Dosage: 25 μM
Administration: Topical application
Result: Reinstated ACTN4-K417 deacetylation and nuclear import.
Increased CSTA expression and reduced wound area at PODs 5, 9, 14, and 18.
Decreased epithelial gap.
Molecular Weight

353.85

Formula

C20H20ClN3O
CAS No.
SMILES

CC(C1=CC=C(C=C1)N2C=CN=C(C2=O)NCC3=CC=CC=C3Cl)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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G194-0712 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G194-07121029737-28-7HDACHistone deacetylasesHDAC5Histone deacetylase 5CSTAACTN4-K417diabetic woundsradiation injury woundsC57BLKS/J-db/dbchronic skin woundsischemic woundsInhibitorinhibitorinhibit

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