63768-47-8
Chemical Structure
MY-1250
- No. CAS: 63768-47-8
- Formula:C15H11NO5
- Molecular Weight:285.26
IUPAC Name: 7,8-dimethyl-4,5-dioxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-2-carboxylic acid
InChIKey: KKCFYNQIBLXNSC-UHFFFAOYSA-N
SMILES: O=C(O)C=1OC=2C=3C=CC(=C(C3NC(=O)C2C(=O)C1)C)C
Biological Activity: MY-1250 is a histamine release inhibitor. MY-1250 is the major active metabolite of Repirinast (HY-109544). MY-1250 stimulates adenylate cyclase to increase intracellular cyclic adenosine monophosphate levels, reduce intracellular ATP levels, inhibit antigen-induced intracellular calcium store mobilization, and induce phosphorylation of the 78 kDa protein. MY-1250 inhibits antigen- and phospholipase A2-induced release of histamine and slow-reacting substance of anaphylaxis from mast cells, lung tissue fragments and basophils. MY-1250 can be used in research related to allergic diseases and bronchial asthma[1][2][3][4].
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MY-1250 | MY-1250 is a histamine release inhibitor. MY-1250 is the major active metabolite of Repirinast (HY-109544). MY-1250 stimulates adenylate cyclase to increase intracellular cyclic adenosine monophosphate levels, reduce intracellular ATP levels, inhibit antigen-induced intracellular calcium store mobilization, and induce phosphorylation of the 78 kDa protein. MY-1250 inhibits antigen- and phospholipase A2-induced release of histamine and slow-reacting substance of anaphylaxis from mast cells, lung tissue fragments and basophils. MY-1250 can be used in research related to allergic diseases and bronchial asthma. | |||||||||||||||||||||
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- [1]. Takei M, et al. Mechanism of action of MY-1250, an active metabolite of Repirinast, in inhibiting histamine release from rat mast cells. British journal of pharmacology. 1992 Mar;105(3):587-90. [Content Brief]
- [2]. Takei M, et al. Inhibition of Histamine Release from Rat Peritoneal Mast Cells by MY-1250, an Active Metabolite of Repirinast (MY-5116). International Archives of Allergy and Immunology. 1990;93(3):237-241. [Content Brief]
- [3]. Takahashi K, et al. Effects of MY-1250, a Main Active Metabolite of MY-5116, a New Anti-allergic Agent, on the Release of Mediators from Guinea Pig Lung Fragments. Japanese Journal of Allergology. 1986;35(9):982-987. [Content Brief]
- [4]. Yamada N, et al. MY-1250, a major metabolite of the anti-allergic drug repirinast, induces phosphorylation of a 78-kDa protein in rat mast cells. Biochemical pharmacology. 1992 Sep 25;44(6):1211-3. [Content Brief]
Keywords
