1. Membrane Transporter/Ion Channel
  2. P-glycoprotein
  3. Elacridar hydrochloride

Elacridar hydrochloride (Synonyms: GF120918A)

Cat. No.: HY-50880 Purity: 98.87%
Handling Instructions

Elacridar Hcl (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.

For research use only. We do not sell to patients.

Elacridar hydrochloride Chemical Structure

Elacridar hydrochloride Chemical Structure

CAS No. : 143851-98-3

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10 mg USD 91 In-stock
Estimated Time of Arrival: December 31
50 mg USD 298 In-stock
Estimated Time of Arrival: December 31
100 mg USD 528 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of Elacridar hydrochloride:

Top Publications Citing Use of Products

    Elacridar hydrochloride purchased from MCE. Usage Cited in: J Drug Target. 2016;24(5):441-9.

    Cells are co-treated with 5 μM of free Raloxifene or an equivalent dose of SMA-raloxifene and either vehicle control (0.01% DMSO), Elacridar (1 μM), KO143 (5 μM), Valspodar (1 μM) or a combination of efflux inhibitors for 6 h.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Elacridar Hcl (GF120918; GW0918) is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. IC50 value: Target: P-glycoprotein In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog plasma. GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro, with IC(50) values well above concentrations anticipated to be achieved in vivo. Together, these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 5 mg/mL (8.33 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6664 mL 8.3319 mL 16.6639 mL
    5 mM 0.3333 mL 1.6664 mL 3.3328 mL
    10 mM --- --- ---
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Elacridar hydrochloride is dissolved in deionized water[6].

    References
    Molecular Weight

    600.10

    Formula

    C₃₄H₃₄ClN₃O₅

    CAS No.

    143851-98-3

    SMILES

    O=C1C2=CC=CC(C(NC(C=C3)=CC=C3CCN4CC(C=C(C(OC)=C5)OC)=C5CC4)=O)=C2NC6=C1C=CC=C6OC.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere

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    × = ×
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    Product Name:
    Elacridar hydrochloride
    Cat. No.:
    HY-50880
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    Elacridar hydrochloride

    Cat. No.: HY-50880