1. Membrane Transporter/Ion Channel
  2. P-glycoprotein
  3. Elacridar hydrochloride

Elacridar hydrochloride (Synonyms: GF120918A)

Cat. No.: HY-50880 Purity: 99.73%
Handling Instructions

Elacridar hydrochloride (GF120918A) is a potent P-glycoprotein (Pgp) and BCRP inhibitor.

For research use only. We do not sell to patients.

Elacridar hydrochloride Chemical Structure

Elacridar hydrochloride Chemical Structure

CAS No. : 143851-98-3

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Customer Review

Based on 11 publication(s) in Google Scholar

Other Forms of Elacridar hydrochloride:

Top Publications Citing Use of Products

    Elacridar hydrochloride purchased from MCE. Usage Cited in: J Drug Target. 2016;24(5):441-9.

    Cells are co-treated with 5 μM of free LY139481 or an equivalent dose of SMA-LY139481 and either vehicle control (0.01% DMSO), Elacridar (1 μM), KO143 (5 μM), Valspodar (1 μM) or a combination of efflux inhibitors for 6 h.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Elacridar hydrochloride (GF120918A) is a potent P-glycoprotein (Pgp) and BCRP inhibitor[1].

    Molecular Weight

    600.10

    Formula

    C₃₄H₃₄ClN₃O₅

    CAS No.

    143851-98-3

    SMILES

    O=C1C2=CC=CC(C(NC(C=C3)=CC=C3CCN4CC(C=C(C(OC)=C5)OC)=C5CC4)=O)=C2NC6=C1C=CC=C6OC.[H]Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 5 mg/mL (8.33 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6664 mL 8.3319 mL 16.6639 mL
    5 mM 0.3333 mL 1.6664 mL 3.3328 mL
    10 mM --- --- ---
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 2.08 mg/mL (3.47 mM); Suspended solution; Need ultrasonic

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.73%

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    Keywords:

    ElacridarGF120918AP-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243Inhibitorinhibitorinhibit

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    Product Name:
    Elacridar hydrochloride
    Cat. No.:
    HY-50880
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