PGK1-IN-2
PGK1-IN-2 (Compound 60) is a PGK1 inhibitor with an IC50 of 8.24 μM. PGK1-IN-2 demonstrates a significant ability to inhibit the proliferation of osteosarcoma cells. PGK1-IN-2 interferes with the glycolytic pathway of tumor cells by inhibiting PGK1. PGK1-IN-2 inhibits cell migration and invasion, and induces cell S phase and G2-M phase cycle arrest. PGK1-IN-2 may kill cells by inducing cuproptosis. PGK1-IN-2 shows a significant anti-tumor effect in the MNNG-HOS osteosarcoma xenograft mouse model. PGK1-IN-2 can be used for the study of osteosarcoma.
For research use only. We do not sell to patients.
- CAS No.: 3054148-68-1
- Formula: C20H24N4O4S
- Molecular Weight:416.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
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PGK1 8.24 μM (IC50) |
Chemical Information
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CAS No. 3054148-68-1
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Molecular Weight 416.49
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Formula C20H24N4O4S
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SMILES
COCCCCNC(C1=NC(C2N(C3=NC=CC=C3OC)C(CS2)=O)=CC=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PGK1-IN-2 Related Classifications
HY-178989 Related Classifications
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