NSC 689534
Based on 1 publication(s) in Google Scholar
NSC 689534 can form copper chelate with Cu2+. NSC 689534/Cu2+ complex is a potent oxidative stress inducer, and has antitumor activity.
For research use only. We do not sell to patients.
- Purity: 96.31%
- CAS No.: 907958-80-9
- Formula: C19H18N6S
- Molecular Weight:362.45
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) NSC 689534
More
Biological Activity
NSC 689534/Cu2+ complex (48 h) inhibits cell viability of HL60 and PC3 cell with IC50s of 0.2 and 0.4 μM respectively, which is about 4 times more potent than NSC 689534 alone[1].
NSC 689534/Cu2+ complex (2.5 μM, 24 h) induces oxidative stress and depletes GSH in PC3 cells, whereas with no effect by NSC 689534 alone[1].
NSC 689534/Cu2+ complex (2.5 μM, 24 h) induces macroautophagy (indicated by LC3 accumulation into large autophagosomes) and an ER-stress response (upregulation of GRP78 and CHOP) in PC3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 907958-80-9
-
Appearance Solid
-
Molecular Weight 362.45
-
Formula C19H18N6S
-
Color Light yellow to yellow
-
SMILES
S=C(N(CC1=NC=CC=C1)CC2=NC=CC=C2)N/N=C/C3=NC=CC=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Front Biosci (Landmark Ed)
Novel Signaling Pathway and NSC689534 as a Potential Drug Candidate for Cutaneous Squamous Cell Carcinoma. [Abstract]2024 Jan 17;29(1):19. PMID: 38287820
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
-
Handling Instructions (2659 KB)
References
[1]. Chad N Hancock, et al. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21. [Content Brief]
[2]. Hancock CN, et al. A copper chelate of thiosemicarbazone NSC 689534 induces oxidative/ER stress and inhibits tumor growth in vitro and in vivo. Free Radic Biol Med. 2011 Jan 1;50(1):110-21. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz