1. Membrane Transporter/Ion Channel Anti-infection
  2. Proton Pump Bacterial Fungal
  3. Zinc Pyrithione

Zinc Pyrithione 

Cat. No.: HY-B0572 Purity: 99.49%
COA Handling Instructions

Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump. Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis.

For research use only. We do not sell to patients.

Zinc Pyrithione Chemical Structure

Zinc Pyrithione Chemical Structure

CAS No. : 13463-41-7

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 61 In-stock
Solution
10 mM * 1 mL in DMSO USD 61 In-stock
Solid
500 mg USD 55 In-stock
1 g USD 73 In-stock
5 g USD 119 In-stock
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Customer Review

Based on 4 publication(s) in Google Scholar

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Description

Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump[1]. Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis[2].

In Vitro

Zinc pyrithione is considered as a coordination complex of zinc. The pyrithione ligands, which are formally monoanions, are chelated to Zn 2+ via oxygen and sulfur centers. In the crystalline state, zinc pyrithione exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers. In solution, however, the dimers dissociate via scission of one Zn-O bond. Zinc pyrithione, which is a dimer but is probably biologically active as a monomer, induces plasma membrane depolarization with half-maximal effect (K1/2) of about 0.3 mM[1].
Zinc Pyrithione (10 nM-10 μM; 72 hours) significantly induces cell death in AAVS1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

317.69

Formula

C10H8N2O2S2Zn

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N12[O-][Zn+2]3([S]=C1C=CC=C2)[O-]N(C=CC=C4)C4=[S]3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (104.91 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1477 mL 15.7386 mL 31.4772 mL
5 mM 0.6295 mL 3.1477 mL 6.2954 mL
10 mM 0.3148 mL 1.5739 mL 3.1477 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.87 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Zinc Pyrithione
Cat. No.:
HY-B0572
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