Tetraethylenepentamine pentahydrochloride

Name: Tetraethylenepentamine pentahydrochloride
Brand: MedChemExpress
SKU: HY-B2153
Rating: 4.5 (0 reviews)

製品番号: HY-B2153 純度: 99.79%: Data Sheet SDS COA 取扱説明書
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Tetraethylenepentamine pentahydrochloride is an orally active copper chelator and copper mobilizer. Tetraethylenepentamine pentahydrochloride exhibits growth inhibitory and hypolipidemic properties. Tetraethylenepentamine pentahydrochloride significantly increases urinary copper excretion and reduces renal copper accumulation in copper overload models, but does not significantly alter hepatic copper levels. Tetraethylenepentamine pentahydrochloride exerts growth inhibitory effects on Candida albicans and Fluconazole (HY-B0101)-resistant strains, and can be widely used in studies related to Wilson's disease and Candida infections.

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Tetraethylenepentamine pentahydrochloride 構造式

CAS 番号 : 4961-41-5

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	USD 55	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 55	在庫あり	Estimated Time of Arrival: December 31
Solid
25 mg	$50	在庫あり	Estimated Time of Arrival: December 31
50 mg	$60	在庫あり	Estimated Time of Arrival: December 31
100 mg	$72	在庫あり	Estimated Time of Arrival: December 31
250 mg	$108	在庫あり	Estimated Time of Arrival: December 31
500 mg	$162	在庫あり	Estimated Time of Arrival: December 31
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製品説明

体外実験

Tetraethylenepentamine pentahydrochloride (10 μM; 24 h) inhibits growth of Candida albicans ATCC 90028 and Fluconazole (HY-B0101)-resistant Candida albicans strain Q181103513 by 94%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	Candida albicans ATCC 90028 and fluconazole-resistant Candida albicans strain Q181103513
Concentration:	10 μM
Incubation Time:	24 h
Result:	Inhibited growth of Candida albicans ATCC 90028 and Fluconazole (HY-B0101)-resistant Candida albicans strain Q181103513 by 94%.

体内実験

Tetraethylenepentamine pentahydrochloride (TETREN) (0.67 mmol/kg/d; p.o.; twice daily; 5 days) is the most effective chelator tested, inducing an 18-fold increase in urinary copper excretion, significantly reducing fecal copper excretion and renal copper levels by 50% in copper-overloaded rats, without significantly lowering hepatic copper levels^[1].
Co-administration of tetraethylenepentamine pentahydrochloride (TETREN) (0.67 mmol/kg/d; p.o.; twice daily; 5 days) and zinc acetate (2.5 mg Zn/kg/d; p.o.; daily; 5 days) induces a 14-fold increase in urinary copper excretion, significantly reducing fecal copper excretion and renal copper levels in copper-overloaded rats, with efficacy slightly lower than TETREN alone^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley Rat (adult male, 200-220 g, copper overload model)^[1]
Dosage:	0.67 mmol/kg/d
Administration:	p.o.; twice daily; 5 days
Result:	Induced an 18-fold significant increase in cumulative urinary copper excretion over 5 days compared to the positive control group. Caused a significant reduction in cumulative fecal copper excretion compared to the positive control group. Did not significantly reduce hepatic copper levels, but significantly reduced renal copper concentrations by approximately 50% compared to the positive control group. Did not produce a significant reduction in brain or spleen copper concentrations relative to the positive control group.

分子量

371.61

分子式

C₈H₂₈Cl₅N₅

CAS 番号

4961-41-5

Appearance

Solid

Color

White to off-white

SMILES

NCCNCCNCCNCCN.[H]Cl.[H]Cl.[H]Cl.[H]Cl.[H]Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

溶剤 & 溶解度

体外:

H₂O : 175 mg/mL (470.92 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6910 mL	13.4550 mL	26.9099 mL
5 mM	0.5382 mL	2.6910 mL	5.3820 mL
10 mM	0.2691 mL	1.3455 mL	2.6910 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

純度とドキュメンテーション

純度: 99.79%

Select Batch:

データシート (271 KB) SDS (393 KB)

COA (243 KB) HNMR (251 KB) RP-HPLC (242 KB) MS (85 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Domingo JL, et al. Comparative efficacy of several potential treatments for copper mobilization in copper-overloaded rats. Biol Trace Elem Res. 2000;74(2):127-139. [Content Brief]

[2]. Yousfi H, et al. Repurposing of ribavirin as an adjunct therapy against invasive Candida strains in an in vitro study[J]. Antimicrobial Agents and Chemotherapy, 2019, 63(10): 10.1128/aac. 00263-19.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	2.6910 mL	13.4550 mL	26.9099 mL	67.2748 mL
	5 mM	0.5382 mL	2.6910 mL	5.3820 mL	13.4550 mL
	10 mM	0.2691 mL	1.3455 mL	2.6910 mL	6.7275 mL
	15 mM	0.1794 mL	0.8970 mL	1.7940 mL	4.4850 mL
	20 mM	0.1345 mL	0.6727 mL	1.3455 mL	3.3637 mL
	25 mM	0.1076 mL	0.5382 mL	1.0764 mL	2.6910 mL
	30 mM	0.0897 mL	0.4485 mL	0.8970 mL	2.2425 mL
	40 mM	0.0673 mL	0.3364 mL	0.6727 mL	1.6819 mL
	50 mM	0.0538 mL	0.2691 mL	0.5382 mL	1.3455 mL
	60 mM	0.0448 mL	0.2242 mL	0.4485 mL	1.1212 mL
	80 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.8409 mL
	100 mM	0.0269 mL	0.1345 mL	0.2691 mL	0.6727 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.