Tetraethylenepentamine pentahydrochloride
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Tetraethylenepentamine pentahydrochloride is an orally active copper chelator and copper mobilizer. Tetraethylenepentamine pentahydrochloride exhibits growth inhibitory and hypolipidemic properties. Tetraethylenepentamine pentahydrochloride significantly increases urinary copper excretion and reduces renal copper accumulation in copper overload models, but does not significantly alter hepatic copper levels. Tetraethylenepentamine pentahydrochloride exerts growth inhibitory effects on Candida albicans and Fluconazole (HY-B0101)-resistant strains, and can be widely used in studies related to Wilson's disease and Candida infections.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 4961-41-5
- Formula: C8H28Cl5N5
- Molecular Weight:371.61
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Storage:
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Tetraethylenepentamine pentahydrochloride (10 μM; 24 h) inhibits growth of Candida albicans ATCC 90028 and Fluconazole (HY-B0101)-resistant Candida albicans strain Q181103513 by 94%[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Candida albicans ATCC 90028 and fluconazole-resistant Candida albicans strain Q181103513
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Concentration:10 μM
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Incubation Time:24 h
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Result:Inhibited growth of Candida albicans ATCC 90028 and Fluconazole (HY-B0101)-resistant Candida albicans strain Q181103513 by 94%.
Co-administration of tetraethylenepentamine pentahydrochloride (TETREN) (0.67 mmol/kg/d; p.o.; twice daily; 5 days) and zinc acetate (2.5 mg Zn/kg/d; p.o.; daily; 5 days) induces a 14-fold increase in urinary copper excretion, significantly reducing fecal copper excretion and renal copper levels in copper-overloaded rats, with efficacy slightly lower than TETREN alone[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley Rat (adult male, 200-220 g, copper overload model)[1]
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Dosage:0.67 mmol/kg/d
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Administration:p.o.; twice daily; 5 days
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Result:Induced an 18-fold significant increase in cumulative urinary copper excretion over 5 days compared to the positive control group.
Caused a significant reduction in cumulative fecal copper excretion compared to the positive control group.
Did not significantly reduce hepatic copper levels, but significantly reduced renal copper concentrations by approximately 50% compared to the positive control group.
Did not produce a significant reduction in brain or spleen copper concentrations relative to the positive control group.
Chemical Information
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CAS No. 4961-41-5
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Appearance Solid
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Molecular Weight 371.61
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Formula C8H28Cl5N5
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Color White to off-white
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SMILES
NCCNCCNCCNCCN.[H]Cl.[H]Cl.[H]Cl.[H]Cl.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
H2O : 175 mg/mL (470.92 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.6910 mL | 13.4550 mL | 26.9099 mL | 67.2748 mL |
| 5 mM | 0.5382 mL | 2.6910 mL | 5.3820 mL | 13.4550 mL | |
| 10 mM | 0.2691 mL | 1.3455 mL | 2.6910 mL | 6.7275 mL | |
| 15 mM | 0.1794 mL | 0.8970 mL | 1.7940 mL | 4.4850 mL | |
| 20 mM | 0.1345 mL | 0.6727 mL | 1.3455 mL | 3.3637 mL | |
| 25 mM | 0.1076 mL | 0.5382 mL | 1.0764 mL | 2.6910 mL | |
| 30 mM | 0.0897 mL | 0.4485 mL | 0.8970 mL | 2.2425 mL | |
| 40 mM | 0.0673 mL | 0.3364 mL | 0.6727 mL | 1.6819 mL | |
| 50 mM | 0.0538 mL | 0.2691 mL | 0.5382 mL | 1.3455 mL | |
| 60 mM | 0.0448 mL | 0.2242 mL | 0.4485 mL | 1.1212 mL | |
| 80 mM | 0.0336 mL | 0.1682 mL | 0.3364 mL | 0.8409 mL | |
| 100 mM | 0.0269 mL | 0.1345 mL | 0.2691 mL | 0.6727 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tetraethylenepentamine pentahydrochloride Related Classifications
HY-B2153 Related Classifications
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- Tetraethylenepentamine pentahydrochloride
- 4961-41-5
- Cuproptosis
- Bacterial
- renal copper accumulation
- urinary copper excretion
- candida infections
- hepatic copper levels
- Wilson’s disease
- fluconazole-resistant Candida albicans
- copper-overloaded rats
- copper chelator
- copper mobilizer
- Candida albicans
- Inhibitor
- inhibitor
- inhibit