Sodium diatrizoate
Based on 1 Customer Validation
Sodium diatrizoate (Diatrizoic acid sodium salt) is an iodinated radiocontrast agent and has the potential for radiographic imaging of the airways. Sodium diatrizoate induces mitochondrial turnover and oxidative stress, and activating apoptosis by dysregulating calcium.
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 737-31-5
- Formula: C11H8I3N2NaO4
- Molecular Weight:635.90
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
HK-2 cells are exposed to 0-30 mg I/mL Sodium diatrizoate (Diatrizoic acid sodium salt) or vehicle for 2-24 h. MTT and trypan blue exclusion indicate a decrease in mitochondrial and cell viability within 2 and 24 h, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 737-31-5
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Appearance Solid
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Molecular Weight 635.90
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Formula C11H8I3N2NaO4
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Color White to off-white
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SMILES
O=C(O[Na])C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I
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Synonyms
Diatrizoic acid sodium salt; Sodium amidotrizoate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (157.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 50 mg/mL (78.63 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 33.33 mg/mL (52.41 mM); Clear solution; Need ultrasonic
Protocol
Female Sprague-Dawley rats (200 to 250 grams) are housed in temperature and humidity controlled rooms with free access to food and water and maintained on a 12 h light/dark cycle. Rats are anesthetized by a 67.5 mg/kg ketamine, 3.5 mg/kg xylazine and 0.66 mg/kg acepromazine subcutaneous cocktail. While under anesthesia, rats are placed on a heating pad to maintain a body temperature of 37°C. Sodium diatrizoate nanoparticle agglomerates (10 mg) is administered by intratracheal insufflation using a dry powder insufflator. At the end of the experiment, the rats are euthanized by isoflurane inhalation overdose followed by harvest of major organs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. El-Gendy N, et al. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm. 2010 May 31;391(1-2):305-12. [Content Brief]
[2]. Dakota B Ward, et al. Radiocontrast Agent Diatrizoic Acid Induces Mitophagy and Oxidative Stress via Calcium Dysregulation. Int J Mol Sci. 2019 Aug 21;20(17):4074. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 1.5726 mL | 7.8629 mL | 15.7257 mL | 39.3144 mL |
| 5 mM | 0.3145 mL | 1.5726 mL | 3.1451 mL | 7.8629 mL | |
| 10 mM | 0.1573 mL | 0.7863 mL | 1.5726 mL | 3.9314 mL | |
| 15 mM | 0.1048 mL | 0.5242 mL | 1.0484 mL | 2.6210 mL | |
| 20 mM | 0.0786 mL | 0.3931 mL | 0.7863 mL | 1.9657 mL | |
| 25 mM | 0.0629 mL | 0.3145 mL | 0.6290 mL | 1.5726 mL | |
| 30 mM | 0.0524 mL | 0.2621 mL | 0.5242 mL | 1.3105 mL | |
| 40 mM | 0.0393 mL | 0.1966 mL | 0.3931 mL | 0.9829 mL | |
| 50 mM | 0.0315 mL | 0.1573 mL | 0.3145 mL | 0.7863 mL | |
| 60 mM | 0.0262 mL | 0.1310 mL | 0.2621 mL | 0.6552 mL | |
| DMSO | 80 mM | 0.0197 mL | 0.0983 mL | 0.1966 mL | 0.4914 mL |
| 100 mM | 0.0157 mL | 0.0786 mL | 0.1573 mL | 0.3931 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium diatrizoate Related Classifications
HY-B0926A Related Classifications
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