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Diatrizoic acid (Synonyms: Diatrizoate; Amidotrizoic acid)

Cat. No.: HY-B0926 Purity: 99.60%
Handling Instructions

Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent.

For research use only. We do not sell to patients.

Diatrizoic acid Chemical Structure

Diatrizoic acid Chemical Structure

CAS No. : 117-96-4

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
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Description

Diatrizoic acid (Diatrizoate) is an iodinated radiocontrast agent.

In Vivo

Diatrizoic acid is an iodinated radiocontrast agent. Histological examination of rat lung tissue shows no acute toxicity or inflammation after insufflation of Diatrizoic acid nanoparticle agglomerates. Diatrizoic acid nanoparticle agglomerates offers a promising radiocontrast agent for safe and effective lung visualization[1].

Clinical Trial
Molecular Weight

613.91

Formula

C₁₁H₉I₃N₂O₄

CAS No.

117-96-4

SMILES

O=C(O)C1=C(I)C(NC(C)=O)=C(I)C(NC(C)=O)=C1I

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (162.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6289 mL 8.1445 mL 16.2890 mL
5 mM 0.3258 mL 1.6289 mL 3.2578 mL
10 mM 0.1629 mL 0.8145 mL 1.6289 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[1]

Female Sprague-Dawley rats (200 to 250 grams) are housed in temperature and humidity controlled rooms with free access to food and water and maintained on a 12 h light/dark cycle. Rats are anesthetized by a 67.5 mg/kg ketamine, 3.5 mg/kg xylazine and 0.66 mg/kg acepromazine subcutaneous cocktail. While under anesthesia, rats are placed on a heating pad to maintain a body temperature of 37°C. Diatrizoic acid nanoparticle agglomerates (10 mg) is administered by intratracheal insufflation using a dry powder insufflator. At the end of the experiment, the rats are euthanized by isoflurane inhalation overdose followed by harvest of major organs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

Diatrizoic acidDiatrizoateAmidotrizoic acidOthersInhibitorinhibitorinhibit

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