854402-59-8
Chemical Structure
SNJ-1945
- CAS No.: 854402-59-8
- Formula:C25H37N3O7
- Molecular Weight:491.58
IUPAC Name: 2-(2-methoxyethoxy)ethyl ((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-phenylbutan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate
InChIKey: PMEQLUMDXFJNRY-SFTDATJTSA-N
SMILES: O=C(C(NC1CC1)=O)[C@@H](NC([C@H](CC(C)C)NC(OCCOCCOC)=O)=O)CC2=CC=CC=C2
Biological Activity: SNJ-1945 is an orally active Calpain inhibitor that can cross the blood-brain barrier. SNJ-1945 protects rat hearts against cardiac arrest-reperfusion injury by inhibiting the hydrolysis of α-fodrin. SNJ-1945 inhibits VEGF-induced angiogenesis in retinal endothelial cells. SNJ-1945 also protects SH-SY5Y cells from damage induced by MPP+ (HY-W008719) and Rotenone (HY-B1756). SNJ-1945 exhibits anti-inflammatory and neuroprotective activities in a mouse model of multiple sclerosis. SNJ-1945 can be used for the research of cardiovascular, nervous system and inflammatory diseases[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SNJ-1945 | 99.49% | SNJ-1945 is an orally active Calpain inhibitor that can cross the blood-brain barrier. SNJ-1945 protects rat hearts against cardiac arrest-reperfusion injury by inhibiting the hydrolysis of α-fodrin. SNJ-1945 inhibits VEGF-induced angiogenesis in retinal endothelial cells. SNJ-1945 also protects SH-SY5Y cells from damage induced by MPP+ (HY-W008719) and Rotenone (HY-B1756). SNJ-1945 exhibits anti-inflammatory and neuroprotective activities in a mouse model of multiple sclerosis. SNJ-1945 can be used for the research of cardiovascular, nervous system and inflammatory diseases. | ||||||||||||||||||||
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- [1]. Yoshikawa Y, et al. Cardioprotective effects of a novel calpain inhibitor SNJ-1945 for reperfusion injury after cardioplegic cardiac arrest. Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H643-51. [Content Brief]
- [2]. Ma H, et al. Calpain inhibitor SNJ-1945 attenuates events prior to angiogenesis in cultured human retinal endothelial cells. J Ocul Pharmacol Ther. 2009 Oct;25(5):409-14. [Content Brief]
- [3]. Knaryan VH, et al. SNJ-1945, a calpain inhibitor, protects SH-SY5Y cells against MPP(+) and rotenone. J Neurochem. 2014 Jul;130(2):280-90. [Content Brief]
- [4]. Trager N, et al. Effects of a novel orally administered calpain inhibitor SNJ-1945 on immunomodulation and neurodegeneration in a murine model of multiple sclerosis. J Neurochem. 2014 Jul;130(2):268-79. [Content Brief]
Keywords
