Laduviglusib dihydrochloride (Synonyms: CHIR-99021 dihydrochloride; CT99021 dihydrochloride)

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Laduviglusib;CHIR 99021;CHIR99021;CHIR-99021;CT99021;CT 99021;CT-99021

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Laduviglusib dihydrochloride Chemical Structure

CAS No. : 2109414-84-6

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Other In-stock Forms of Laduviglusib dihydrochloride:

Laduviglusib Laduviglusib monohydrochloride Laduviglusib trihydrochloride

Other Forms of Laduviglusib dihydrochloride:

141 Publications Citing Use of MCE Laduviglusib dihydrochloride

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: Laduviglusib dihydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2020 Apr 2;524(2):280-287. [Abstract]; Western blot analysis of Tcf7l1 protein levels in mESCs pre-treated with the indicative different small molecules for 1 h and then treated with CHIR for 24 h.

: Laduviglusib dihydrochloride purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2020 Apr 2;524(2):280-287. [Abstract]; Western blot analysis of Tcf7l1 protein levels in mESCs pre-treated with D4476 or DMAT and then treated with CHIR or PD03 for 24 h.

: Laduviglusib dihydrochloride purchased from MedChemExpress. Usage Cited in: Chemosphere. 2018 Oct 23;216:372-378. [Abstract]; AhR mediates EOM-inhibited cardiac differentiation by downregulating β-catenin expression in P19 cells. mRNA expression changes of β-catenin by Q-PCR. The concentrations of CH (CH223191, AhR antagonist) and CHIR (CHIR99021, Wnt activator) are 0.25 and 0.5 μM respectively.

: Laduviglusib dihydrochloride purchased from MedChemExpress. Usage Cited in: Chemosphere. 2018 Oct 23;216:372-378. [Abstract]; AhR mediates EOM-inhibited cardiac differentiation by downregulating β-catenin expression in P19 cells. Percentage of cTnT positive cells at differentiation day 14. The concentrations of CH (CH223191, AhR antagonist) and CHIR (CHIR99021, Wnt activator) are 0.25 and 0.5 μM respectively.

: Laduviglusib dihydrochloride purchased from MedChemExpress. Usage Cited in: Chemosphere. 2018 Oct 23;216:372-378. [Abstract]; AhR mediates EOM-inhibited cardiac differentiation by downregulating β-catenin expression in P19 cells. Percentage of cTnT positive cells at differentiation day 14. The concentrations of CH (CH223191, AhR antagonist) and CHIR (CHIR99021, Wnt activator) are 0.25 and 0.5 μM respectively.

: Laduviglusib dihydrochloride purchased from MedChemExpress. Usage Cited in: Toxicology. 2016 May 20;355-356:31-38. [Abstract]; Western analysis of β-catenin protein level in zebrafish embryos exposed to EOM in the presence or absence of CH/CHIR (n = 3). Different letters indicate significant differences. Moreover, both CH and CHIR attenuate the EOM-induced changes in the protein level of b-catenin and in EROD activity.

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Description	Laduviglusib;CHIR 99021;CHIR99021;CHIR-99021;CT99021;CT 99021;CT-99021
IC₅₀ & Target	IC50: 10 nM/6.7 nM (GSK-3α/β)^[1]
Molecular Weight	538.26
Formula	C₂₂H₂₀Cl₄N₈
CAS No.	2109414-84-6
SMILES	N#CC1=CC=C(N=C1)NCCNC2=NC=C(C(C3=CC=C(Cl)C=C3Cl)=N2)C4=NC=C(N4)C.[H]Cl.[H]Cl
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (272 KB) Handling Instructions (2659 KB)
References	[1]. Ring DB, et al. Selective glycogen synthase kinase 3 inhibitors potentiate activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003 Mar;52(3):588-95. [Content Brief] [2]. Naujok O, et al. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors.BMC Res Notes. 2014 Apr 29;7:273. [Content Brief] [3]. Ye S, et al. Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One. 2012;7(4):e35892. [Content Brief]

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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Laduviglusib dihydrochloride (Synonyms: CHIR-99021 dihydrochloride; CT99021 dihydrochloride)

Other Forms of Laduviglusib dihydrochloride:

Laduviglusib dihydrochloride Related Antibodies

141 Publications Citing Use of MCE Laduviglusib dihydrochloride

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All GSK-3 Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review