2. Academic Validation
  3. Vitamin C Suppresses Pancreatic Carcinogenesis through the Inhibition of Both Glucose Metabolism and Wnt Signaling

Vitamin C Suppresses Pancreatic Carcinogenesis through the Inhibition of Both Glucose Metabolism and Wnt Signaling

  • Int J Mol Sci. 2022 Oct 14;23(20):12249. doi: 10.3390/ijms232012249.
Ji Hye Kim 1,  Sein Hwang 1,  Ji-Hye Lee 1,  Se Seul Im 1,  Jaekyoung Son 1
Affiliations

Affiliation

  • 1 Department of Biomedical Sciences, Asan Medical Center, AMIST, University of Ulsan College of Medicine, Seoul 05505, Korea.
PMID: 36293106 DOI: 10.3390/ijms232012249
Abstract

Cumulative studies have indicated that high-dose vitamin C has antitumor effects against a variety of cancers. However, the molecular mechanisms underlying these inhibitory effects against tumorigenesis and metastasis, particularly in relation to pancreatic Cancer, are unclear. Here, we report that vitamin C at high concentrations impairs the growth and survival of pancreatic ductal adenocarcinoma (PDAC) cells by inhibiting glucose metabolism. Vitamin C was also found to trigger Apoptosis in a caspase-independent manner. We further demonstrate that it suppresses the invasion and metastasis of PDAC cells by inhibiting the Wnt/β-catenin-mediated epithelial-mesenchymal transition (EMT). Taken together, our results suggest that vitamin C has therapeutic effects against pancreatic Cancer.

Keywords

PDAC; Vitamin C; Wnt signaling; glucose metabolism; metastasis.

Figures
Products