GSK-3 alpha
GSK-3 alpha, encoded by GSK3A, is one of two closely related mammalian isoforms of glycogen synthase kinase-3. It behaves as a constitutively active serine/threonine kinase that is restrained by insulin-stimulated Akt phosphorylation at Ser21 near its N terminus. Its canonical substrate, glycogen synthase, is inhibited upon phosphorylation, coupling the kinase directly to glucose storage; other reported targets include tau, linking GSK-3 alpha to Alzheimer-type neurodegeneration. Relative to the widely studied GSK-3 beta, the alpha isoform shows a more restricted expression pattern and non-redundant contributions to hepatic glucose homeostasis and sperm function. Both isoforms are inhibited by lithium and remain drug targets in metabolic and neuropsychiatric disease.
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GSK-3 alpha Recombinant Proteins (1)
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Inhibitors & Agonists (49)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
