1. Metabolic Enzyme/Protease
  2. Gutathione S-transferase
  3. GSTO-IN-2

GSTO-IN-2 

Cat. No.: HY-112534
Handling Instructions

GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.

For research use only. We do not sell to patients.

GSTO-IN-2 Chemical Structure

GSTO-IN-2 Chemical Structure

CAS No. : 1202710-57-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 751 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3950 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

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  • References

Description

GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.

IC50 & Target

IC50: 3.6 μM (GSTA2), 16.3 μM (GSTM1), 1.4 μM (GSTP1-1)[1]

In Vitro

GSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231.[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
Molecular Weight

620.77

Formula

C₃₃H₅₂N₂O₉

CAS No.

1202710-57-3

SMILES

C[[email protected]@]1(-;@[[email protected]@]2([H])[[email protected]](C)CCC(O)=O)-;@[[email protected]](-;@C-;@C-;@2)([H])-;@[[email protected]@](-;@C-;@C-;@[[email protected]@]3([H])-;@[[email protected]@]-;@4(-;@C-;@C-;@[[email protected]@H](OC([[email protected]@H](NC(CC[[email protected]@H](C(O)=O)N)=O)CC(O)=O)=O)-;@C-;@3)C)([H])-;@[[email protected]]4([H])-;@C-;@C-;@1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
GSTO-IN-2
Cat. No.:
HY-112534
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GSTO-IN-2

Cat. No.: HY-112534