1. Metabolic Enzyme/Protease
  2. Gutathione S-transferase
  3. Ezatiostat

Ezatiostat (Synonyms: TER199(free base); TLK199)

Cat. No.: HY-13634A Purity: >96.0%
Handling Instructions

Ezatiostat (TER199 free base; TLK199) is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

For research use only. We do not sell to patients.

Ezatiostat Chemical Structure

Ezatiostat Chemical Structure

CAS No. : 168682-53-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 112 In-stock
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 162 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg USD 816 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Other Forms of Ezatiostat:

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Description

Ezatiostat (TER199 free base; TLK199) is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

In Vitro

Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone[1].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (188.80 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8880 mL 9.4402 mL 18.8804 mL
5 mM 0.3776 mL 1.8880 mL 3.7761 mL
10 mM 0.1888 mL 0.9440 mL 1.8880 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (5.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.75 mg/mL (5.19 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (5.19 mM); Clear solution

References
Molecular Weight

529.65

Formula

C₂₇H₃₅N₃O₆S

CAS No.

168682-53-9

SMILES

O=C(OCC)[[email protected]@H](C1=CC=CC=C1)NC([[email protected]@H](NC(CC[[email protected]](N)C(OCC)=O)=O)CSCC2=CC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

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Product Name:
Ezatiostat
Cat. No.:
HY-13634A
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Ezatiostat

Cat. No.: HY-13634A