1. Metabolic Enzyme/Protease
  2. Gutathione S-transferase

Ezatiostat (Synonyms: TER199; TLK199)

Cat. No.: HY-13634A Purity: 96.84%
Handling Instructions

Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

For research use only. We do not sell to patients.

Ezatiostat Chemical Structure

Ezatiostat Chemical Structure

CAS No. : 168682-53-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 112 In-stock
Estimated Time of Arrival: December 31
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 162 In-stock
Estimated Time of Arrival: December 31
50 mg USD 480 In-stock
Estimated Time of Arrival: December 31
100 mg USD 816 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Ezatiostat:

Customer Validation

    Ezatiostat purchased from MCE. Usage Cited in: Cell Res. 2018 Oct 4.

    Melanoma A375 cells are treated with SSZ (Sulfasalazine, 125 μM) with or without FeSO4 (100 μM) for 6 h to detect the ROS level or 24 h to assess the pyroptotic features (including morphology, GSDME cleavage, and LDH release), unless specifically defined.

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    Description

    Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

    In Vitro

    Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone[1].

    Solvent & Solubility
    In Vitro: 

    10 mM in DMSO

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.8880 mL 9.4402 mL 18.8804 mL
    5 mM 0.3776 mL 1.8880 mL 3.7761 mL
    10 mM 0.1888 mL 0.9440 mL 1.8880 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    529.65

    Formula

    C₂₇H₃₅N₃O₆S

    CAS No.

    168682-53-9

    SMILES

    O=C(OCC)[[email protected]@H](C1=CC=CC=C1)NC([[email protected]@H](NC(CC[[email protected]](N)C(OCC)=O)=O)CSCC2=CC=CC=C2)=O

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    • Molarity Calculator

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Inquiry Information

    Product Name:
    Ezatiostat
    Cat. No.:
    HY-13634A
    Quantity:

    Ezatiostat

    Cat. No.: HY-13634A