1. Metabolic Enzyme/Protease
  2. Gutathione S-transferase

Ezatiostat (Synonyms: TER199; TLK199)

Cat. No.: HY-13634A Purity: 96.84%
Data Sheet SDS Handling Instructions

Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

For research use only. We do not sell to patients.
Ezatiostat Chemical Structure

Ezatiostat Chemical Structure

CAS No. : 168682-53-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $93 In-stock
5 mg $80 In-stock
10 mg $135 In-stock
50 mg $400 In-stock
100 mg $680 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Ezatiostat:

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Ezatiostat is a glutathione analog inhibitor of glutathione S-transferase P1-1 (GSTP1-1).

In Vitro

Ezatiostat causes dissociation of the enzyme from the jun-N-terminal kinase/c-Jun (JNK/JUN) complex, leading to JNK activation by phosphorylation. The therapeutic action of ezatiostat appears to include both proliferation of normal myeloid progenitors as well as apoptosis of the malignant clone[1].

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT01422486 Telik Myelodysplastic Syndrome (MDS) October 2011 Phase 2
NCT01459159 Telik Myelodysplastic Syndrome (MDS) October 2011 Phase 2
NCT00909584 Telik Severe Chronic Neutropenia April 2009 Phase 2
NCT01062152 Telik Myelodysplastic Syndrome November 2009 Phase 1
NCT00701870 Telik Non-small Cell Lung Cancer October 2008 Phase 2
NCT00700206 Telik Myelodysplastic Syndrome (MDS) May 2008 Phase 2
NCT00280631 Telik Myelodysplastic Syndrome (MDS) February 2006 Phase 1|Phase 2
NCT00035867 Telik Myelodysplastic Syndromes April 2002 Phase 1|Phase 2
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.8880 mL 9.4402 mL 18.8804 mL
5 mM 0.3776 mL 1.8880 mL 3.7761 mL
10 mM 0.1888 mL 0.9440 mL 1.8880 mL
References
Molecular Weight

529.65

Formula

C₂₇H₃₅N₃O₆S

CAS No.

168682-53-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Ezatiostat
Cat. No.:
HY-13634A
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