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Ezatiostat hydrochloride

(Synonyms: TER199; TLK199 hydrochloride)
8 Cited Publications
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Based on 8 publication(s) in Google Scholar

Ezatiostat hydrochloride (TER199; TLK199 hydrochloride) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat hydrochloride leads to JNK activation by inhibiting GSTP1. Ezatiostat hydrochloride stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat hydrochloride has the potential for myelodysplastic syndrome (MDS) treatment.

For research use only. We do not sell to patients.

  • CAS No.: 286942-97-0
  • Formula: C27H36ClN3O6S
  • Molecular Weight:566.11
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Ezatiostat hydrochloride Chemical Structure
    Ezatiostat hydrochloride Chemical Structure
  • Experimental Validation Results for Ezatiostat hydrochloride
  • Experimental Validation Results for Ezatiostat hydrochloride
  • Experimental Validation Results for Ezatiostat hydrochloride
  • Experimental Validation Results for Ezatiostat hydrochloride
  • Experimental Validation Results for Ezatiostat hydrochloride
  • Experimental Validation Results for Ezatiostat hydrochloride
CAS No.: 286942-97-0
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Cell Proliferation/Viability AssayBio/Physico-chemical AssayIn Vivo Efficacy StudyWB
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  • Cell Proliferation/Viability Assay
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  • Cell Proliferation/Viability Assay
  • In Vivo Efficacy Study
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  • Ezatiostat hydrochloride Chemical Structure
    Ezatiostat hydrochloride Chemical Structure
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    Ezatiostat hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Oct:76:103323. [Abstract]

    Customer Validation
     Huh7 cells were treated with 0, 5, 10, and 20 μM Ezatiostat (TLK199) for 72 h, followed by FACS analysis to assess ROS production.

  • 1/16

    Ezatiostat hydrochloride purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Oct:76:103323. [Abstract]

    Customer Validation
     Protein expression levels of Lamin B1, p21, γ-H2AX and H2AX were detected by western blot upon treatment of Ezatiostat (TLK199, 0-20 μM, 72 h), with β-actin as a loading control.

  • 1/16

    Ezatiostat hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Mar;10(7):e2205262. [Abstract]

    Customer Validation
     In vitro effects of treatment with the GSTP1 inhibitor Ezatiostat (12.5 μM) on crizotinib sensitivity in LUAD-OG1 evaluated by Cell titer-Glo cell viability assay.

  • 1/16

    Ezatiostat hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Mar;10(7):e2205262. [Abstract]

    Customer Validation
     Schematic diagram of the treatment regimen with 1% Tween 80/saline (Group 1), crizotinib (10 mg/kg; Group2), ezatiostat (25 mg/kg; Group 3), or the combination of ezatiostat with crizotinib (Group 4) in NOD-SCID mice. n = 4 mice per group. Representative image of LUAD-OG1 xenografts from the four groups at the endpoint are shown.

  • 1/16

    Ezatiostat hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Mar;10(7):e2205262. [Abstract]

    Customer Validation
     Ex vivo effects of GSTP1 inhibitor Ezatiostat (12.5 and 25 μM) treatment on crizotinib sensitivity in crizotinib-resistant LUAD-OG1 evaluated by Cell titer-Glo cell viability assay.

  • 1/16

    Ezatiostat hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Mar;10(7):e2205262. [Abstract]

    Customer Validation
     Schematic diagram of oral gavage of the treatment regimen with 1% Tween 80/saline (Group 1), crizotinib (25 mg kg−1; Group2), ezatiostat (25 mg/kg; Group 3), or the combination of ezatiostat with crizotinib (Group 4) in SCID mice.

  • Ezatiostat hydrochloride