1. Metabolic Enzyme/Protease
  2. Gutathione S-transferase
  3. TK05

TK05 

Cat. No.: HY-117143
Handling Instructions

TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM.

For research use only. We do not sell to patients.

TK05 Chemical Structure

TK05 Chemical Structure

CAS No. : 1245734-61-5

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Description

TK05 is a potent and selective inhibitor of leukotriene C4 synthase (LTC4S) with an IC50 of 95 nM[1].

IC50 & Target

IC50: 95 nM (Leukotriene C4 synthase)[1]

In Vitro

TK05 reduces LTC4 production in a dose-dependent manner with an IC50 value of 318 ± 60 nM in MM6 Cells[1].

In Vivo

TK05 (0.12-6 mg/kg; given i.p.; only once) significantly reduces LTE4 levels[1].

Animal Model: Zymosan A induced peritonitis mouse model[1]
Dosage: 0.12 mg/kg; 6 mg/kg
Administration: Given i.p.; only once
Result: 0.12 mg/kg of TK05 significantly reduced LTE4 levels, whereas 6 mg/kg body weight of the compound resulted in almost complete inhibition compared with mice treated with only Zymosan A.
Molecular Weight

540.99

Formula

C₃₁H₂₅ClN₂O₅

CAS No.

1245734-61-5

SMILES

ClC1=CC=C(N(CC2CC2)C3=CC=C(C(C4=CC(C(O)=O)=C(C(C5=CC=C(OC)C=C5)=O)C=C4)=O)N=C3)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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