1. Metabolic Enzyme/Protease
  2. Gutathione S-transferase
  3. AZD9898

AZD9898 

Cat. No.: HY-126329
Handling Instructions

AZD9898 is an oral leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma.

For research use only. We do not sell to patients.

AZD9898 Chemical Structure

AZD9898 Chemical Structure

CAS No. : 2042347-69-1

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Description

AZD9898 is an oral leukotriene-C4 synthetase (LTC4S, glutathione S-transferase II) inhibitor, with an IC50 of 0.28 nM. AZD9898 mitigates the GABA binding and hepatic toxicity signal. AZD9898 has the potential to treat asthma[1].

IC50 & Target

IC50: 0.28 nM (LTC4S)[1].

In Vivo

AZD9898 with the single dose of 100 mg/kg is well tolerated and no safety concerns are raised[1].

Animal Model: Rat 6M/group[1].
Dosage: 10 and 100 mg/kg (for Toxicology Study).
Administration: Sing oral dose.
Result: Showed no signs of testicular toxicity, and only adaptive changes in the liver due to cytochrome P450 induction which were not judged adverse, providing a 200 fold margin between the no adverse effect level and the predicted human exposure at the predicted therapeutic dose.
Molecular Weight

457.83

Formula

C₂₀H₁₉ClF₃N₃O₄

CAS No.

2042347-69-1

SMILES

O=C([[email protected]@H]1[[email protected]@H](C(C2=NC=C(N(C3=CC(Cl)=C(F)C=C3F)CC(C)(F)C)N=C2OC)=O)C1)O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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