NCAM-1/CD56 Protein, Cynomolgus (HEK293, His)

NCAM-1/CD56 protein is an important cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, and neurite outgrowth. It interacts with MDK and forms a complex with SLC39A6 and SLC39A10, complexly regulating NCAM-1 phosphorylation. NCAM-1/CD56 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived NCAM-1/CD56 protein, expressed by HEK293 , with C-His labeled tag.

The NCAM-1/CD56 protein takes on a pivotal role as a cell adhesion molecule, participating in neuron-neuron adhesion, neurite fasciculation, and the outgrowth of neurites. It engages in interactions with MDK and forms a complex with SLC39A6, SLC39A10, and itself. This complex intricately regulates NCAM-1 phosphorylation and facilitates its integration into focal adhesion complexes during epithelial-to-mesenchymal transition, as observed in studies. The versatile involvement of NCAM-1 in cell adhesion and signaling processes highlights its significance in mediating complex cellular interactions critical for neuronal development and transitions between epithelial and mesenchymal states.

Cynomolgus

HEK293

C-8*His

XP_005579710.1 (L20-G718)

102144192  [NCBI]

Partial

LQVDIVPSQGEISVGESKFFLCQVAGDAKDKDISWFSPNGEKLTPNQQRISVVWNDDSSSTLTIYNANIDDAGIYKCVVTGEDGSESEATVNVKIFQKLMFKNAPTPQEFREGEDAVIVCDVVSSLPPTIIWKHKGRDVILKKDVRFIVLSNNYLQIRGIKKTDEGTYRCEGRILARGEINFKDIQVVVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFPEPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFAKPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQETLDGHMVVRSHARVSSLTLKSIQYTDAGEYICTASNTIGQDSQSMYLEVQYAPKLQGPVAVYTWEGNQVNITCEVFAYPSATISWFRDGQLLPSSNYSNIKIYNTPSASYLEVTPDSENDFGNYNCTAVNRIGQESLEFILVQADTPSSPSIDQVEPYSSTAQVQFDEPEATGGVPILKYKAEWRAVGEEVWHSKWYDAKEASMEGIVTIVGLKPETTYAVRLAALNGKGLGEISAASEFKTQPVQGEPSAPKLEGQMGEDGNSIKVNLIKQDDGGSPIRHYLVRYRALSSEWKPEIRLPSGSDHVMLKSLDWNAEYEVYVVAENQQGKSKAAHFVFRTSAQPTAIPANGSPTSG

95-115 kDa

≥ 95%, as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of 50 mM Tris, 500 mM NaCl, pH 8.0.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.

• [1]. /biology-dictionary/sf9-cell.html  [Content Brief]