1. Metabolic Enzyme/Protease
  2. NEDD8-activating Enzyme

ZM223 

Cat. No.: HY-101790
Handling Instructions

ZM223 is a novel non-sulfamide NEDD8 activating enzyme inhibitor that inhibits HCT116 colon cancer cells with an IC50 value of 100 nM.

For research use only. We do not sell to patients.

ZM223 Chemical Structure

ZM223 Chemical Structure

CAS No. : 2031177-48-5

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

ZM223 is a novel non-sulfamide NEDD8 activating enzyme inhibitor that inhibits HCT116 colon cancer cells with an IC50 value of 100 nM.

IC50 & Target

IC50: 100 nM (HCT116), 122 nM (U-2OS)[1]

In Vitro

ZM223 exhibits excellent antitumor activities against both HCT116 and U-2OS cells (IC50=100, 122 nM)[1].

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.1, 1 μM
Incubation Time: 4 hours
Result: ZM223 inhibited NEDD8 protein and subsequently elevated UBC12 level[1].
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9899 mL 9.9497 mL 19.8993 mL
5 mM 0.3980 mL 1.9899 mL 3.9799 mL
10 mM 0.1990 mL 0.9950 mL 1.9899 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

502.53

Formula

C₂₃H₁₇F₃N₄O₂S₂

CAS No.

2031177-48-5

SMILES

O=C(C1=CC=C(C(F)(F)F)C=C1)NC2=NC3=CC=C(NC(CSC4=CC=C(N)C=C4)=O)C=C3S2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
ZM223
Cat. No.:
HY-101790
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ZM223

Cat. No.: HY-101790