951950-33-7
951950-33-7
Chemical Structure
NAE-IN-3
- CAS No.: 951950-33-7
- Formula:C17H18N4O6
- Molecular Weight:374.35
InChIKey: BGFQHCHLBHLYBO-UHFFFAOYSA-N
SMILES: O=C(CNC(CNC(COC1=CC2=C(N=C3N(CCC3)C2=O)C=C1)=O)=O)O
Biological Activity: NAE-IN-3 (compound 1) is a potent, selective and non-covalent competitive NEDD8-activating enzyme (NAE) inhibitor (IC50 = 0.8 μM). NAE-IN-3 inhibits NAE by blocking the ATP-binding domain. NAE-IN-3 exhibits selectivity over analogous E1 enzymes UAE and SAE. NAE-IN-3 can be used for cancer research[1].
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NAE-IN-3 | NAE-IN-3 (compound 1) is a potent, selective and non-covalent competitive NEDD8-activating enzyme (NAE) inhibitor (IC50 = 0.8 μM). NAE-IN-3 inhibits NAE by blocking the ATP-binding domain. NAE-IN-3 exhibits selectivity over analogous E1 enzymes UAE and SAE. NAE-IN-3 can be used for cancer research. | |||||||||||||||||||||
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References
Keywords
