1. Metabolic Enzyme/Protease
  2. NEDD8-activating Enzyme
  3. TAS4464

TAS4464 

Cat. No.: HY-128586 Purity: 98.55%
Handling Instructions

TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM.

For research use only. We do not sell to patients.

TAS4464 Chemical Structure

TAS4464 Chemical Structure

CAS No. : 1848959-10-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 391 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 650 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TAS4464:

Top Publications Citing Use of Products
  • Biological Activity

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Description

TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM[1].

IC50 & Target

IC50:0.955 nM (NAE)[1]

In Vitro

TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

506.51

Formula

C₂₁H₂₃FN₆O₆S

CAS No.

1848959-10-3

SMILES

NC1=NC=NC2=C1C(C#CC3=C(F)C=CC=C3OCC)=CN2[[email protected]@H]4O[[email protected]](CNS(=O)(N)=O)[[email protected]@H](O)[[email protected]]4O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (78.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9743 mL 9.8715 mL 19.7429 mL
5 mM 0.3949 mL 1.9743 mL 3.9486 mL
10 mM 0.1974 mL 0.9871 mL 1.9743 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (3.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2 mg/mL (3.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.55%

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Keywords:

TAS4464TAS 4464TAS-4464NEDD8-activating EnzymeNAEInhibitorinhibitorinhibit

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Product Name:
TAS4464
Cat. No.:
HY-128586
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