1. Metabolic Enzyme/Protease
  2. NEDD8-activating Enzyme
  3. TAS4464

TAS4464 

Cat. No.: HY-128586
Handling Instructions

TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM.

For research use only. We do not sell to patients.

TAS4464 Chemical Structure

TAS4464 Chemical Structure

CAS No. : 1848959-10-3

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Description

TAS4464 is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM[1].

IC50 & Target

IC50:0.955 nM (NAE)[1]

In Vitro

TAS4464 treatment inhibits cullin neddylation and subsequently induces the accumulation of CRL substrates such as CDT1, p27, and phosphorylates IκBα in 47 human cancer cell lines.

Molecular Weight

506.51

Formula

C₂₁H₂₃FN₆O₆S

CAS No.

1848959-10-3

SMILES

NC1=NC=NC2=C1C(C#CC3=C(F)C=CC=C3OCC)=CN2[[email protected]@H]4O[[email protected]](CNS(=O)(N)=O)[[email protected]@H](O)[[email protected]]4O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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TAS4464
Cat. No.:
HY-128586
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