1. Metabolic Enzyme/Protease
  2. NEDD8-activating Enzyme
  3. TAS4464 hydrochloride

TAS4464 hydrochloride 

Cat. No.: HY-128586A Purity: 98.01%
Handling Instructions

TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM.

For research use only. We do not sell to patients.

TAS4464 hydrochloride Chemical Structure

TAS4464 hydrochloride Chemical Structure

CAS No. : 1848959-11-4

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 418 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2000 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TAS4464 hydrochloride:

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Description

TAS4464 (hydrochloride) is a highly potent and selective inhibitor of NEDD8 activating enzyme (NAE), with an IC50 of 0.955 nM[1].

IC50 & Target

IC50:0.955 nM (NAE)[1]

Clinical Trial
Molecular Weight

542.97

Formula

C₂₁H₂₄ClFN₆O₆S

CAS No.

1848959-11-4

SMILES

NC1=NC=NC2=C1C(C#CC3=C(F)C=CC=C3OCC)=CN2[[email protected]@H]4O[[email protected]](CNS(=O)(N)=O)[[email protected]@H](O)[[email protected]]4O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (153.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8417 mL 9.2086 mL 18.4172 mL
5 mM 0.3683 mL 1.8417 mL 3.6834 mL
10 mM 0.1842 mL 0.9209 mL 1.8417 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

TAS4464TAS 4464TAS-4464NEDD8-activating EnzymeNAEInhibitorinhibitorinhibit

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Product Name:
TAS4464 hydrochloride
Cat. No.:
HY-128586A
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