1. Metabolic Enzyme/Protease
  2. NEDD8-activating Enzyme
  3. NAcM-OPT

NAcM-OPT 

Cat. No.: HY-111505
Handling Instructions

NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction.

For research use only. We do not sell to patients.

NAcM-OPT Chemical Structure

NAcM-OPT Chemical Structure

CAS No. : 2089293-61-6

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Description

NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction[1].

IC50 & Target

DCN1[1]

In Vitro

NAcM-OPT (Compound 67) is orally bioavailable, well tolerated in mice, and currently used to study the effects of acute pharmacologic inhibition of the DCN1-UBE2M interaction on the NEDD8/CUL pathway[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (287.75 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3020 mL 11.5101 mL 23.0203 mL
5 mM 0.4604 mL 2.3020 mL 4.6041 mL
10 mM 0.2302 mL 1.1510 mL 2.3020 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

434.40

Formula

C₂₃H₂₉Cl₂N₃O

CAS No.

2089293-61-6

SMILES

O=C(NC1=CC=C(Cl)C(Cl)=C1)N(C2CCN(CCCC)CC2)CC3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
NAcM-OPT
Cat. No.:
HY-111505
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NAcM-OPT

Cat. No.: HY-111505