NEDD8-activating Enzyme Activator
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AM9053
0 ImagesAM9053 is a selective NAAA inhibitor. AM9053 inhibits NAAA catalytic activity, reduces N-acylethanolamine degradation and elevates PEA/OEA levels, indirectly activating PPAR-α and TRPV1, thereby exerting antiproliferative effects. AM9053 reduces LPS-induced nitrite production in microglia, counteracts colitis, and attenuates TNBS-induced intestinal fibrosis disease activity, collagen deposition, and fibrosis-related gene expression. AM9053 modulates macrophage polarization, macrophage-fibroblast crosstalk, T helper cell subset balance, IL-23/STAT3 signaling, and EMT-related genes. AM9053 inhibits colorectal cancer proliferation and migration, induces S phase arrest, downregulates cyclin A2/CDK2, and reduces xenograft tumor growth and azoxymethane-induced colon tumorigenesis. AM9053 can be used for research on colitis, intestinal fibrosis, and colorectal cancer.
