2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage Membrane Transporter/Ion Channel Neuronal Signaling Immunology/Inflammation
  3. Ceramidase PPAR TRP Channel Interleukin Related NEDD8-activating Enzyme
  4. AM9053

AM9053 is a selective, effective and slowly reversible inhibitor of N-acyl ethanolamine acid amidease (NAAA) (IC50 = 30 nM). The effect of AM9053 on FAAH activity is limited (IC50 > 100 nM). AM9053 inhibits the proliferation of colorectal cancer cells by activating the PPAR-α and TRPV1 dependent mechanisms and induces S-phase cell cycle arrest. AM9053 alleviates intestinal fibrosis by regulating macrophage activity and inhibiting the IL-23 signaling pathway. AM9053 leads to an increase in NAE levels, especially PEA and OEA. AM9053 can be used for the study of colorectal cancer and intestinal fibrosis.

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AM9053

AM9053 Chemical Structure

CAS No. : 157469-21-1

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AM9053 Related Antibodies

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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TRPA1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM8 TRPM2 TRPM3 TRPM4 TRPM7 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

AM9053 is a selective, effective and slowly reversible inhibitor of N-acyl ethanolamine acid amidease (NAAA) (IC50 = 30 nM). The effect of AM9053 on FAAH activity is limited (IC50 > 100 nM). AM9053 inhibits the proliferation of colorectal cancer cells by activating the PPAR-α and TRPV1 dependent mechanisms and induces S-phase cell cycle arrest. AM9053 alleviates intestinal fibrosis by regulating macrophage activity and inhibiting the IL-23 signaling pathway. AM9053 leads to an increase in NAE levels, especially PEA and OEA. AM9053 can be used for the study of colorectal cancer and intestinal fibrosis[1][2][3].

IC50 & Target[2][3]

PPARα

 

TRPV1

 

IL-23

 

Molecular Weight

275.45

Formula

C17H25NS
CAS No.
Appearance

Liquid

Color

Light yellow to yellow

SMILES

S=C=NCCCCCCCCCCC1=CC=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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AM9053 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM9053157469-21-1AM 9053AM-9053CeramidasePPARTRP ChannelInterleukin RelatedNEDD8-activating EnzymePeroxisome proliferator-activated receptorsTransient receptor potential channelsILNAENAAA inhibitioncolorectal cancerintestinal fibrosisN-acylethanolaminesPPAR-αTRPV1IL-23 signalingmacrophage modulationanticancer therapyantifibrotic treatmentInhibitorinhibitorinhibit

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