1. Metabolic Enzyme/Protease
  2. ROR
  3. TMP920

TMP920 

Cat. No.: HY-117819
Handling Instructions

TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC50 of 0.03 μM.

For research use only. We do not sell to patients.

TMP920 Chemical Structure

TMP920 Chemical Structure

CAS No. : 1421837-45-7

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Description

TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC50 of 0.03 μM[1].

IC50 & Target

IC50: 0.03 μM (RORγt)[1]

In Vitro

TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Naïve CD4+ T cells[1].
TMP920 suppresses Th17 cell differentiation and lost its IL-17 inhibitory effect at <2.5 μM in vitro[1].
TMP920 suppresses IL-17 production from differentiated Th17 cells in vitro[1].
TMP920 suppresses the Th17 cell transcriptome and promotes alternate T-cell subsets[1].
TMP920 significantly reduces RORγt-DNA interactions[1].

Cell Cytotoxicity Assay[1]

Cell Line: Naïve CD4 + T cells
Concentration: 0.09-30 μM
Incubation Time: 48 hours
Result: Has toxic effects on cell growth at >10 μM.
Molecular Weight

454.56

Formula

C₂₉H₃₀N₂O₃

CAS No.

1421837-45-7

SMILES

O=C(NC(C1=CC=C(C=C1C)C)C2=CC=CC=C2)CC3=CC=C(C=C3)OCC4=C(ON=C4C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TMP920TMP 920TMP-920RORRAR-related orphan receptorRORγtTh17cellsdifferentiationInhibitorinhibitorinhibit

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