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  3. TMP920

TMP920 

Cat. No.: HY-117819 Purity: 99.88%
Handling Instructions

TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC50 of 0.03 μM.

For research use only. We do not sell to patients.

TMP920 Chemical Structure

TMP920 Chemical Structure

CAS No. : 1421837-45-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 209 In-stock
Estimated Time of Arrival: December 31
5 mg USD 190 In-stock
Estimated Time of Arrival: December 31
10 mg USD 325 In-stock
Estimated Time of Arrival: December 31
50 mg USD 970 In-stock
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100 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC50 of 0.03 μM[1].

IC50 & Target

IC50: 0.03 μM (RORγt)[1]

In Vitro

TMP920 (0.09-30 μM) starts to show toxic effects on cell growth at >10 μM in Naïve CD4+ T cells[1].
TMP920 suppresses Th17 cell differentiation and lost its IL-17 inhibitory effect at <2.5 μM in vitro[1].
TMP920 suppresses IL-17 production from differentiated Th17 cells in vitro[1].
TMP920 suppresses the Th17 cell transcriptome and promotes alternate T-cell subsets[1].
TMP920 significantly reduces RORγt-DNA interactions[1].

Cell Cytotoxicity Assay[1]

Cell Line: Naïve CD4 + T cells
Concentration: 0.09-30 μM
Incubation Time: 48 hours
Result: Has toxic effects on cell growth at >10 μM.
Molecular Weight

454.56

Formula

C₂₉H₃₀N₂O₃

CAS No.

1421837-45-7

SMILES

O=C(NC(C1=CC=C(C=C1C)C)C2=CC=CC=C2)CC3=CC=C(C=C3)OCC4=C(ON=C4C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (137.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1999 mL 10.9996 mL 21.9993 mL
5 mM 0.4400 mL 2.1999 mL 4.3999 mL
10 mM 0.2200 mL 1.1000 mL 2.1999 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

TMP920TMP 920TMP-920RORRAR-related orphan receptorRORγtTh17cellsdifferentiationInhibitorinhibitorinhibit

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TMP920
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