1. Apoptosis
  2. Caspase

Selonsertib (Synonyms: GS-4997; GS4997; GS 4997)

Cat. No.: HY-18938 Purity: >98.0%
Data Sheet SDS Handling Instructions

GS-4997 is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain.

For research use only. We do not sell to patients.
Selonsertib Chemical Structure

Selonsertib Chemical Structure

CAS No. : 1448428-04-3

Size Price Stock Quantity
Free sample   Apply now  
10 mM * 1 mL in DMSO $77 In-stock
5 mg $70 In-stock
10 mg $120 In-stock
50 mg $350 In-stock
100 mg $550 In-stock
200 mg $900 In-stock
500 mg   Get quote  
1 g   Get quote  

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Description

GS-4997 is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain. target: ASK1 GS-4997 is a once daily, oral molecule that inhibits Apoptosis Signal-regulating Kinase 1 (ASK1), which is a key mediator of the deleterious effects of oxidative stress. GS-4997 has anti-inflammatory and anti-fibrotic properties.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02509624 Gilead Sciences Diabetic Kidney Disease August 2015 Phase 1
NCT02466516 Gilead Sciences Non-Alcoholic Steatohepatitis (NASH) June 2015 Phase 2
NCT03087968 HepQuant, LLC Severe Alcoholic Hepatitis August 31, 2016 Early Phase 1
NCT02854631 Gilead Sciences Alcoholic Hepatitis (AH) August 31, 2016 Phase 2
NCT02177786 Gilead Sciences Diabetic Kidney Disease June 2014 Phase 2
NCT02234141 Gilead Sciences Pulmonary Arterial Hypertension November 2014 Phase 2
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References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.2447 mL 11.2236 mL 22.4472 mL
5 mM 0.4489 mL 2.2447 mL 4.4894 mL
10 mM 0.2245 mL 1.1224 mL 2.2447 mL
References
M.Wt

445.49

Formula

C₂₄H₂₄FN₇O

CAS No.

1448428-04-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 31 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: >98.0%

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Product Name:
Selonsertib
Cat. No.:
HY-18938
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