1. MAPK/ERK Pathway
  2. MAP3K

Selonsertib (Synonyms: GS-4997)

Cat. No.: HY-18938 Purity: 99.12%
Handling Instructions

Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3±0.07.

For research use only. We do not sell to patients.

Selonsertib Chemical Structure

Selonsertib Chemical Structure

CAS No. : 1448428-04-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 119 In-stock
Estimated Time of Arrival: December 31
50 mg USD 348 In-stock
Estimated Time of Arrival: December 31
100 mg USD 552 In-stock
Estimated Time of Arrival: December 31
200 mg USD 828 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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  • Biological Activity

  • Technical Information

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  • References

Description

Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3±0.07.

IC50 & Target[1]

ASK1

8.3 (pIC50)

In Vitro

Selonsertib (GS-4997) is a clinical stage ASK1 inhibitor, which has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis[1]. Selonsertib (GS-4997) is a highly selective and potent once-daily oral ASK1 inhibitor that competes with ATP in the ASK1 catalytic kinase domain[2].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 31 mg/mL (69.59 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2447 mL 11.2236 mL 22.4472 mL
5 mM 0.4489 mL 2.2447 mL 4.4894 mL
10 mM 0.2245 mL 1.1224 mL 2.2447 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.67 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.67 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.67 mM); Clear solution

References
Molecular Weight

445.49

Formula

C₂₄H₂₄FN₇O

CAS No.

1448428-04-3

SMILES

O=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N4C=C(C5CC5)N=C4)=C(C)C=C3F

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.12%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Selonsertib
Cat. No.:
HY-18938
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Selonsertib

Cat. No.: HY-18938