Copy Link Print Information

Selonsertib hydrochloride

(別名: GS-4997 hydrochloride)
25 Cited Publications
カスタマーレビュー

Based on 25 publication(s) in Google Scholar

Selonsertib hydrochloride (GS-4997 hydrochloride) is an orally bioavailable enzyme inhibitor with potential anti-inflammatory, anti-tumor and anti-fibrotic activities. Selonsertib hydrochloride blocks ASK1 phosphorylation and activation by binding to the catalytic kinase domain. Selonsertib hydrochloride prevents the production of inflammatory cytokines and reduces the expression of genes associated with fibrosis. Selonsertib hydrochloride inhibits excessive apoptosis and limits cell proliferation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

  • CAS 番号: 1448428-05-4
  • 分子式: C24H25ClFN7O
  • 分子量:481.95
  • 保管条件:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Selonsertib hydrochloride Chemical Structure
    Selonsertib hydrochloride 構造式
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
CAS 番号: 1448428-05-4
容量
価格（税別）
在庫状況
数量
Amount: USD 0.00
Please select quantity
or
or

* アイテムを追加する前、数量をご選択ください

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of Selonsertib hydrochloride:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
最寄りの代理店をお探しください Your local distributor: Hycultec GmbHHycultec
  • 生物活性
  • 化学情報
  • 純度とドキュメンテーション
  • 参考文献
  • Help & FAQs
Top Publications Citing

Use of MCE Products

MedChemExpress（MCE）の使用を引用している文献 Selonsertib hydrochloride

More
Customer Validation & Images
Histological Imaging/StainingELISAIFCell Imaging/StainingIHCOthersCell Proliferation/Viability Assay
  • IF
  • Others
  • Histological Imaging/Staining
  • ELISA
  • IHC
  • Cell Imaging/Staining
  • Cell Imaging/Staining
  • Cell Proliferation/Viability Assay

MAP3K アイソフォーム固有の製品をすべて表示

More
Keywords
MOQ
Minimum order quantity
100 mg

お問い合わせ 在庫あり

Other size
お問い合わせ
Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress ログイン
Register
Sign in to MedChemExpress
新規会員登録

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • Selonsertib hydrochloride Chemical Structure
    Selonsertib hydrochloride Chemical Structure
    1/16
  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Sep;15(9):4789-4806. [Abstract]

    Customer Validation
     Immunofluorescence in determining the expression of P4HA1 after treated with Berberine (BBC; p.o.; 20 mg/kg for 7 days ) and Selonsertib (p.o.; 20 mg/kg for 7 days ) in the heart tissue of MI mice. n=3. *P < 0.05, **P < 0.01 vs. Sham, #P < 0.05, ##P < 0.01 vs. MI. Scale bar, 200 µm.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Sep;15(9):4789-4806. [Abstract]

    Customer Validation
     Echocardiographic detection of cardiac function changes in MI mice and treated with Berberine (BBC; p.o.; 20 mg/kg for 7 days ) and Selonsertib (p.o.; 20 mg/kg for 7 days ) . n=3-4. *P < 0.05 vs. Sham, #P < 0.05 vs. MI.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 May 21;8(1):781. [Abstract]

    Customer Validation
     Selonsertib (15 mg/kg; IP; daily) reduced exaggerated inflammation in NOD1-KO mice.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 May 21;8(1):781. [Abstract]

    Customer Validation
     Selonsertib (15 mg/kg; IP; daily) reduced plasma IL-1β levels in the NOD1-KO mice.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 May 21;8(1):781. [Abstract]

    Customer Validation
     Selonsertib (15 mg/kg; IP; daily) reduced IL-1β (magenta) and DAPI (blue) in the coronary arteries of NOD-KO mice.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Biomaterials. 2022 Nov:290:121817. [Abstract]

    Customer Validation
     Selonsertib (Selon; 10 μM; 10 days) slightly decreased the lipid uptake in the MCLS culture.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Biomaterials. 2022 Nov:290:121817. [Abstract]

    Customer Validation
     Selonsertib (Selon; 10 μM; 48 h) slightly decreased the expression of Collagen 1 and lipid accumulation in the MCLS culture.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Phytother Res. 2023 Apr;37(4):1274-1292. [Abstract]

    Customer Validation
     Selonsertib (5 µM) alleviates TMAO-induced morphological changes and improve cellular viability in RTEC cells.

  • Selonsertib hydrochloride