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Selonsertib hydrochloride

(Synonyms: GS-4997 hydrochloride)
25 Cited Publications
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Based on 25 publication(s) in Google Scholar

Selonsertib hydrochloride (GS-4997 hydrochloride) is an orally bioavailable enzyme inhibitor with potential anti-inflammatory, anti-tumor and anti-fibrotic activities. Selonsertib hydrochloride blocks ASK1 phosphorylation and activation by binding to the catalytic kinase domain. Selonsertib hydrochloride prevents the production of inflammatory cytokines and reduces the expression of genes associated with fibrosis. Selonsertib hydrochloride inhibits excessive apoptosis and limits cell proliferation.

For research use only. We do not sell to patients.

  • CAS No.: 1448428-05-4
  • Formula: C24H25ClFN7O
  • Molecular Weight:481.95
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Selonsertib hydrochloride Chemical Structure
    Selonsertib hydrochloride Chemical Structure
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
  • Experimental Validation Results for Selonsertib hydrochloride
CAS No.: 1448428-05-4
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  • Selonsertib hydrochloride Chemical Structure
    Selonsertib hydrochloride Chemical Structure
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    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Sep;15(9):4789-4806. [Abstract]

    Customer Validation
     Immunofluorescence in determining the expression of P4HA1 after treated with Berberine (BBC; p.o.; 20 mg/kg for 7 days ) and Selonsertib (p.o.; 20 mg/kg for 7 days ) in the heart tissue of MI mice. n=3. *P < 0.05, **P < 0.01 vs. Sham, #P < 0.05, ##P < 0.01 vs. MI. Scale bar, 200 µm.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Sep;15(9):4789-4806. [Abstract]

    Customer Validation
     Echocardiographic detection of cardiac function changes in MI mice and treated with Berberine (BBC; p.o.; 20 mg/kg for 7 days ) and Selonsertib (p.o.; 20 mg/kg for 7 days ) . n=3-4. *P < 0.05 vs. Sham, #P < 0.05 vs. MI.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 May 21;8(1):781. [Abstract]

    Customer Validation
     Selonsertib (15 mg/kg; IP; daily) reduced exaggerated inflammation in NOD1-KO mice.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 May 21;8(1):781. [Abstract]

    Customer Validation
     Selonsertib (15 mg/kg; IP; daily) reduced plasma IL-1β levels in the NOD1-KO mice.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 May 21;8(1):781. [Abstract]

    Customer Validation
     Selonsertib (15 mg/kg; IP; daily) reduced IL-1β (magenta) and DAPI (blue) in the coronary arteries of NOD-KO mice.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Biomaterials. 2022 Nov:290:121817. [Abstract]

    Customer Validation
     Selonsertib (Selon; 10 μM; 10 days) slightly decreased the lipid uptake in the MCLS culture.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Biomaterials. 2022 Nov:290:121817. [Abstract]

    Customer Validation
     Selonsertib (Selon; 10 μM; 48 h) slightly decreased the expression of Collagen 1 and lipid accumulation in the MCLS culture.

  • 1/16

    Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Phytother Res. 2023 Apr;37(4):1274-1292. [Abstract]

    Customer Validation
     Selonsertib (5 µM) alleviates TMAO-induced morphological changes and improve cellular viability in RTEC cells.

  • Selonsertib hydrochloride