Art. -Nr.: HY-18938A

Selonsertib hydrochloride

(Synonyms: GS-4997 hydrochloride)

25 Cited Publications

Kundenbewertung

Based on 25 publication(s) in Google Scholar

Selonsertib hydrochloride (GS-4997 hydrochloride) is an orally bioavailable enzyme inhibitor with potential anti-inflammatory, anti-tumor and anti-fibrotic activities. Selonsertib hydrochloride blocks ASK1 phosphorylation and activation by binding to the catalytic kinase domain. Selonsertib hydrochloride prevents the production of inflammatory cytokines and reduces the expression of genes associated with fibrosis. Selonsertib hydrochloride inhibits excessive apoptosis and limits cell proliferation.

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CAS. Nr.: 1448428-05-4
Formel: C₂₄H₂₅ClFN₇O
Molecular Weight:481.95

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Selonsertib hydrochloride Chemical Structure

CAS. Nr.: 1448428-05-4

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Beschreibung

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Chemical Information

CAS. Nr. 1448428-05-4
Molecular Weight 481.95
Formel C₂₄H₂₅ClFN₇O
SMILES

O=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N4C=C(C5CC5)N=C4)=C(C)C=C3F.Cl
Synonyms

GS-4997 hydrochloride
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (25)

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Acta Pharm Sin B

Palmitoylated SARM1 targeting P4HA1 promotes collagen deposition and myocardial fibrosis: A new target for anti-myocardial fibrosis. [Abstract]

2025 Sep;15(9):4789-4806. PMID: 41049740

Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Sep;15(9):4789-4806. [Abstract]

Immunofluorescence in determining the expression of P4HA1 after treated with Berberine (BBC; p.o.; 20 mg/kg for 7 days ) and Selonsertib (p.o.; 20 mg/kg for 7 days ) in the heart tissue of MI mice. n=3. *P < 0.05, **P < 0.01 vs. Sham, #P < 0.05, ##P < 0.01 vs. MI. Scale bar, 200 µm.

Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Sep;15(9):4789-4806. [Abstract]

Echocardiographic detection of cardiac function changes in MI mice and treated with Berberine (BBC; p.o.; 20 mg/kg for 7 days ) and Selonsertib (p.o.; 20 mg/kg for 7 days ) . n=3-4. *P < 0.05 vs. Sham, #P < 0.05 vs. MI.
Biomaterials

Modelling fatty liver disease with mouse liver-derived multicellular spheroids. [Abstract]

2022 Nov:290:121817. PMID: 36208587

Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Biomaterials. 2022 Nov:290:121817. [Abstract]

Selonsertib (Selon; 10 μM; 10 days) slightly decreased the lipid uptake in the MCLS culture.

Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Biomaterials. 2022 Nov:290:121817. [Abstract]

Selonsertib (Selon; 10 μM; 48 h) slightly decreased the expression of Collagen 1 and lipid accumulation in the MCLS culture.
Cell Death Dis

Targeted inhibition of protein synthesis renders cancer cells vulnerable to apoptosis by unfolded protein response. [Abstract]

2023 Aug 26;14(8):561. PMID: 37626037
Phytomedicine

Apigenin ameliorates non-eosinophilic inflammation, dysregulated immune homeostasis and mitochondria-mediated airway epithelial cell apoptosis in chronic obese asthma via the ROS-ASK1-MAPK pathway. [Abstract]

2023 Mar:111:154646. PMID: 36645975
J Hazard Mater

Combined exposure of alumina nanoparticles and chronic stress exacerbates hippocampal neuronal ferroptosis via activating IFN-γ/ASK1/JNK signaling pathway in rats. [Abstract]

2021 Jun 5:411:125179. PMID: 33858114
Acta Pharmacol Sin

Targeting PPARα activation sensitizes glioblastoma cells to temozolomide and reverses acquired resistance by inhibiting H3K18 lactylation. [Abstract]

2025 Jun 11. PMID: 40500345
Basic Res Cardiol

Deubiquitinase USP43 exacerbates myocardial ischemia-reperfusion injury by stabilizing ASK1 and activating the JNK/P38 MAPK pathway. [Abstract]

2026 Jun;121(3):459-479. PMID: 42012501
Apoptosis

The GATA3-RFPL3-ASK1 axis suppresses breast cancer growth and lung metastasis. [Abstract]

2026 Apr 17;31(4):127. PMID: 41995771
Phytother Res

Perilla frutescens L. alleviates trimethylamine N-oxide-induced apoptosis in the renal tubule by regulating ASK1-JNK phosphorylation. [Abstract]

2023 Apr;37(4):1274-1292. PMID: 36420586

Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Phytother Res. 2023 Apr;37(4):1274-1292. [Abstract]

Selonsertib (5 µM) alleviates TMAO-induced morphological changes and improve cellular viability in RTEC cells.
Cell Biosci

Selonsertib, a potential drug for liver failure therapy by rescuing the mitochondrial dysfunction of macrophage via ASK1-JNK-DRP1 pathway. [Abstract]

2021 Jan 7;11(1):9. PMID: 33413667
Life Sci

Galectin-9 in human trophoblast cells: Implications for maternal-fetal immune balance and pregnancy complications. [Abstract]

2026 Mar 1:388:124173. PMID: 41544754
Commun Biol

NOD1 deficiency promotes inflammation via autophagic degradation of ASK1. [Abstract]

2025 May 21;8(1):781. PMID: 40399666

Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 May 21;8(1):781. [Abstract]

Selonsertib (15 mg/kg; IP; daily) reduced exaggerated inflammation in NOD1-KO mice.

Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 May 21;8(1):781. [Abstract]

Selonsertib (15 mg/kg; IP; daily) reduced plasma IL-1β levels in the NOD1-KO mice.

Selonsertib hydrochloride purchased from MedChemExpress. Usage Cited in: Commun Biol. 2025 May 21;8(1):781. [Abstract]

Selonsertib (15 mg/kg; IP; daily) reduced IL-1β (magenta) and DAPI (blue) in the coronary arteries of NOD-KO mice.
Int Immunopharmacol

Monocrotaline induces liver injury via TRX1-ASK1-JNK Axis-mediated mitochondrial damage in hepatocytes. [Abstract]

2026 Mar 1:172:116121. PMID: 41519004
Int Immunopharmacol

PIM1 attenuates renal ischemia-reperfusion injury by inhibiting ASK1-JNK/P38. [Abstract]

2023 Jan:114:109563. PMID: 36513021
Biochim Biophys Acta Mol Basis Dis

PUMA overexpression dissociates thioredoxin from ASK1 to activate the JNK/BCL-2/BCL-XL pathway augmenting apoptosis in ovarian cancer. [Abstract]

2022 Dec 1;1868(12):166553. PMID: 36122664
Sci Rep

Digital pathology with artificial intelligence analysis provides insight to the efficacy of anti-fibrotic compounds in human 3D MASH model. [Abstract]

2024 Mar 11;14(1):5885. PMID: 38467661
Cancers (Basel)

Coxsackievirus Group B3 Has Oncolytic Activity against Colon Cancer through Gasdermin E-Mediated Pyroptosis. [Abstract]

2022 Dec 15;14(24):6206. PMID: 36551691
Neurochem Res

Anti-neuroinflammatory Effects and Brain Pharmacokinetic Properties of Selonsertib, an Apoptosis signal-regulating Kinase 1 Inhibitor, in mice. [Abstract]

2022 Dec;47(12):3829-3837. PMID: 36309631
FASEB J

E3 Ubiquitin Ligase TRIM21 Exacerbates Pathological Cardiac Hypertrophy Through ASK1 K63-Linked Polyubiquitination. [Abstract]

2025 Dec 15;39(23):e71311. PMID: 41359290
Animal Model Exp Med

Targeting ASK1 by CS17919 alleviates kidney- and liver-related diseases in murine models. [Abstract]

2025 Jan;8(1):102-113. PMID: 38873818
PLoS One

A novel small molecule screening assay using normal human chondrocytes toward osteoarthritis drug discovery. [Abstract]

2024 Nov 1;19(11):e0308647. PMID: 39485774
bioRxiv

2026 Jan 25.
University of Oxford

2023 Oct.
Research Square Print

2022 Aug.
Research Square Preprint

2021 Jul.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lanier M, et al. Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure. ACS Med Chem Lett. 2017 Feb 8;8(3):316-320. [Content Brief]

[2]. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials [Content Brief]

[3]. Lin JH, et al. Design of a phase 2 clinical trial of an ASK1 inhibitor, GS-4997, in patients with diabetic kidney disease. Nephron. 2015;129(1):29-33. [Content Brief]

[4]. Loomba R, et al. The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2trial. Hepatology. 2018 Feb;67(2):549-559. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Selonsertib hydrochloride

25 Cited Publications

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Selonsertib hydrochloride

Publications Citing Use of MedChemExpress (MCE) Selonsertib hydrochloride

Alle MAP3K Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (25)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Selonsertib hydrochloride Related Classifications

HY-18938A Related Classifications