1448428-04-3
1448428-04-3
Chemical Structure
Selonsertib
Synonym(s): GS-4997
- CAS. Nr.: 1448428-04-3
- Formula:C24H24FN7O
- Molecular Weight:445.49
IUPAC Name: 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-4-methylbenzamide
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
SMILES: O=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N4C=C(C5CC5)N=C4)=C(C)C=C3F
Biological Activity: Selonsertib (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis.
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Selonsertib | 98.87% | Selonsertib (GS-4997), an orally bioavailable, selective apoptosis signal-regulating kinase 1 (ASK1) inhibitor with a pIC50 of 8.3, has been evaluated as an experimental treatment for diabetic nephropathy and kidney fibrosis. | ||||||||||||||||||||
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