3033697-19-4
Chemical Structure
ZAK-IN-2
- CAS No.: 3033697-19-4
- Formula:C33H26F2N8O4S
- Molecular Weight:668.67
InChIKey: BTVPMDAMCUGYJV-UHFFFAOYSA-N
SMILES: O=C(N1CCC(C1)OC2=NNC3=C2C=C(C4=CN(C5=C(F)C(NS(=O)(C6=CC=CC(C7=CC=CC=C7)=C6)=O)=CC=C5F)N=N4)C=N3)C=C
Biological Activity: ZAK-IN-2 (Compound 8) is a selective, covalent ZAK inhibitor with an IC50 of 11.5 nM. ZAK-IN-2 forms a covalent bond with Cys22 in the P-loop of ZAK to inhibit its kinase activity. ZAK-IN-2 inhibits the phosphorylation of the downstream target p38. ZAK-IN-2 blocks Doxorubicin (HY-15142A)-induced cleavage of Caspase 3. ZAK-IN-2 is applicable to research related to myocardial hypertrophy[1].
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ZAK-IN-2 | ZAK-IN-2 (Compound 8) is a selective, covalent ZAK inhibitor with an IC50 of 11.5 nM. ZAK-IN-2 forms a covalent bond with Cys22 in the P-loop of ZAK to inhibit its kinase activity. ZAK-IN-2 inhibits the phosphorylation of the downstream target p38. ZAK-IN-2 blocks Doxorubicin (HY-15142A)-induced cleavage of Caspase 3. ZAK-IN-2 is applicable to research related to myocardial hypertrophy. | |||||||||||||||||||||
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Keywords
