PVRIG Protein, Human (HEK293, mFc)
The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Human (HEK293, mFc) is the recombinant human-derived PVRIG protein, expressed by HEK293 , with C-mFc labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Human (HEK293, mFc) is the recombinant human-derived PVRIG protein, expressed by HEK293 , with C-mFc labeled tag.
Background
PVRIG (PVR-related immunoglobulin domain-containing) protein is identified as a cell surface receptor for NECTIN2, functioning as a potential coinhibitory receptor that dampens T-cell receptor-mediated signals. Upon interacting with NECTIN2, PVRIG exerts its inhibitory effect by suppressing T-cell proliferation. Notably, PVRIG engages in a competitive binding scenario with CD226 for NECTIN2, implying a regulatory role in immune responses where it competes with an activating receptor. This competitive interaction with CD226 underscores PVRIG's involvement in modulating the delicate balance between activating and inhibitory signals during T-cell activation.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-mFc
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Accession
Q6DKI7 (T41-D171)
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Molecular Construction
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N-term
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PVRIG (T41-D171)
Accession # Q6DKI7 -
mFc
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C-term
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Protein Length
Partial
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Synonyms
PVRIG; Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein; PVR Related Immunoglobulin Domain Containing; Poliovirus Receptor Related Immunoglobulin Domain Containing; C7orf15; Transmembrane Protein PVRIG; CD112R; Nectin-2 Receptor; CD112
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AA Sequence
TPEVWVQVRMEATELSSFTIRCGFLGSGSISLVTVSWGGPNGAGGTTLAVLHPERGIRQWAPARQARWETQSSISLILEGSGASSPCANTTFCCKFASFPEGSWEACGSLPPSSDPGLSAPPTPAPILRAD
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Predicted Molecular Mass
40.1 kDa
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Molecular Weight
Approximately 45-55 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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