PVRIG - PVR related immunoglobulin domain containing Gene

Also Known as CD112R; C7orf15

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79037

About PVRIG

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,219,248-100,221,490 (from NCBI)

This gene has 3 transcripts (splice variants) and 71 orthologues. Broad expression in lymph node (RPKM 13.9), spleen (RPKM 12.7) and 25 other tissues.

Summary

Enables Phosphatase binding activity and signaling receptor activity. Involved in negative regulation of T cell receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PVRIG Products (3)

mRNA Protein Name
NM_001387134.1 NP_001374063.1 transmembrane protein PVRIG isoform 2 precursor
NM_001397246.1 NP_001384175.1 transmembrane protein PVRIG isoform 3 precursor
NM_024070.3 NP_076975.2 transmembrane protein PVRIG isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatase binding IPI
IPI: Inferred from physical interaction
26755705 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26755705 GOA
enables signaling receptor activity IMP
IMP: Inferred from mutant phenotype
26755705 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
26755705 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
26755705 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane protein PVRIG

  • CD112 receptor

PVRIG Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PVRIG Q6DKI7 OLFM4 Homo sapiens Q6UX06
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PVRIG Proteins

Cat. No. Product Name Accession Purity
HY-P71247 PVRIG Protein, Human (HEK293, Fc) Q6DKI7 (T41-D171) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71248 PVRIG Protein, Human (HEK293, mFc) Q6DKI7 (T41-D171) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72409 PVRIG Protein, Human (Biotinylated, HEK293, Fc-Avi) Q6DKI7 (T41-D171) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78922 PVRIG Protein, Human (Biotinylated, HEK293, His-Avi) Q6DKI7 (T41-D171) ≥ 90%, as determined by reducing SDS-PAGE.

PVRIG Antibodies

Cat. No. Product Name Application Reactivity
HY-P84955 CD112R Antibody (YA4647)

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990496 Anti-PVRIG Antibody (COM701) Inhibitor 99.14% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11474 PVRIG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17255 Pvrig Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23709 Pvrig Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992381 IBI352g4a / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PVRIG MGD MGI:5596028
Rattus norvegicus PVRIG RGD RGD:1585866
Felis catus PVRIG VGNC VGNC:64441
Bos taurus PVRIG VGNC VGNC:49566
Others PVRIG NCBI