CD112R Antibody (YA4647)
(Synonyms: Poliovirus receptor-related immunoglobulin domain containing protein; PVRIG; C7orf15; CD112 receptor)CD112R Antibody (YA4647) is a non-conjugated antibody, targeting to CD112R.
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Formulation:
Supplied in Phosphate-buffered solution.
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Conjugation:
Non-conjugated
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Product Details
CD112R Antibody (YA4647) is a non-conjugated antibody, targeting to CD112R.
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Clonality Monoclonal
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in Phosphate-buffered solution.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD112R cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding
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Subcellular Localization
Cell membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-cell expression levels are variable among individuals. Not detected in B-cells, naive or helper T-cells, monocytes, nor neutrophils (at protein level) . Not detected in dendritic cells
Induction:In T-cells, up-regulated by activation induced by treatment with anti-CD3 and anti-CD28 antibodies -
Subunit
Interacts with NECTIN2, hence competing with CD226
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SwissProt ID
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Synonyms
Poliovirus receptor-related immunoglobulin domain containing protein; PVRIG; C7orf15; CD112 receptor
Documentation
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